Ultrasound-Guided Radiofrequency and Microwave Ablation for the Management of Patients With Benign Thyroid Nodules: Systematic Review and Meta-Analysis : Ultrasound Quarterly

Journal Logo

Review Article

Ultrasound-Guided Radiofrequency and Microwave Ablation for the Management of Patients With Benign Thyroid Nodules

Systematic Review and Meta-Analysis

Ding, Jian MM; Wang, Duo MM; Zhang, Wenbin MM; Xu, Dexin MM§; Wang, Wenhai MM

Author Information
Ultrasound Quarterly 39(1):p 61-68, March 2023. | DOI: 10.1097/RUQ.0000000000000636

Abstract

Ultrasound-guided thermal ablation has been shown to considerably reduce nodule-related discomfort and cosmetic problems. Hence, this review was done to determine the effectiveness of ultrasound-guided radiofrequency or microwave ablation in the management of benign thyroid nodules. Searches were done in EMBASE, SCOPUS, PubMed Central, Cochrane library, MEDLINE, Google Scholar, ScienceDirect, and Clinicaltrials.gov until August 2022. Meta-analysis was carried out using random-effects model. With 95% confidence intervals (CIs), pooled standardized mean differences, mean differences, and/or odds ratio reported. In total, we analyzed 16 studies, most of them had high risk of bias. The pooled standardized mean difference for symptom score was −1.01 (95% CI, −1.83 to −0.19; I2 = 94.2%), for cosmetic relief was −1.26 (95% CI, −2.27 to −0.24; I2 = 96%), for postoperative nodule volume was −1.77 (95% CI, −3.06 to −0.48; I2 = 94%), for hospital stay was −3.88 (95% CI, −4.58 to −3.18; I2 = 91.1%), for operation time was −3.30 (95% CI, −3.95 to −2.64; I2 = 93.4%). The pooled odds ratio for postoperative pain was 0.04 (95% CI, 0.00–0.35; I2 = 95.1%), for postoperative hypothyroidism was 0.04 (95% CI, 0.01–0.11; I2 = 0%), for postoperative hoarseness was 0.56 (95% CI, 0.22–1.47; I2 = 0%), for postoperative hematoma was 0.57 (95% CI, 0.15–2.22; I2 = 0%). Ultrasound-guided radiofrequency and microwave ablation had better efficacy and safety profile in terms of symptoms, cosmetic relief, complication rate, duration of stay, and operation time when compared with conventional surgery or observation without treatment for patients with benign thyroid nodules.

Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

You can read the full text of this article if you:

Access through Ovid