Pictorial EssayContrast-Enhanced Ultrasound-Guided Interventions—The New Sheriff in Town? A Case-Based Review of Problem Solving With Ultrasound ContrastCaserta, Melanie P. MD∗; Dahiya, Nirvikar MD†; Tchelepi, Hisham MD‡Author Information ∗Division of Ultrasonography, Mayo Clinic, Jacksonville, Florida †Division of Ultrasonography, Mayo Clinic, Scottsdale, Arizona ‡Division of Ultrasonography, Keck School of Medicine, University of Southern California, Los Angeles, California. Received for publication January 3, 2019; accepted March 25, 2019. Hisham Tchelepi has received research grants from the General Electric and CIVCO Medical Solutions. The other authors declare no conflict of interest. Address correspondence to: Melanie P. Caserta, MD, Division of Ultrasonography, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224 (e-mail: Caserta.Melanie@mayo.edu). Ultrasound Quarterly: June 2020 - Volume 36 - Issue 2 - p 91-101 doi: 10.1097/RUQ.0000000000000455 Buy Metrics Abstract Ultrasound (US)–guided intervention is a well-established medical procedure and offers advantages such as real-time guidance, portability, reduced cost, shortened procedure time compared with computed tomography, and lack of ionizing radiation. Ultrasound contrast agents (UCAs) are a useful adjunct to US-guided procedures. The addition of microbubble UCAs during US-guided interventions can assist with biopsy planning and lesion selection, aid in identification of target lesions, and direct the biopsy toward viable tissue. Ultrasound contrast agents have been in use outside of the United States for many years and have been used off label at select institutions across the United States before the Food and Drug Administration approval of Lumason (Bracco Diagnostics) for liver lesion evaluation in April 2016. After Food and Drug Administration approval, the use of UCAs has expanded rapidly, and UCAs are being used for a variety of clinical applications. Ultrasound contrast agents have been shown to be safe, and there is no renal toxicity. In this article, we will discuss the indications and techniques for using contrast-enhanced ultrasound during US-guided interventions, and we will present case examples where contrast-enhanced ultrasound added value. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.