Heart Transplantation in the Middle East Gulf Region Bader, Feras; Atallah, Bassam; Rizk, John; More Bader, Feras; Atallah, Bassam; Rizk, John; AlHabeeb, Waleed Less Transplantation. 102(7):1023-1026, July 2018. Favorites PDF Get Content & Permissions
Research Highlights Issa, Fadi Issa, Fadi Less Transplantation. 102(7):1026-1027, July 2018. Favorites PDF Get Content & Permissions
Stop TRPC5 in Kidney Disease: A Game Changer for Renal Allograft Protection? Wang, Xuexiang; Reiser, Jochen Wang, Xuexiang; Reiser, Jochen Less Transplantation. 102(7):1027-1029, July 2018. Favorites PDF Get Content & Permissions
Yolanda Becker, MD: President of UNOS, Professor of Surgery, University of Chicago Becker, Yolanda Becker, Yolanda Less Transplantation. 102(7):1029-1030, July 2018. Favorites PDF Get Content & Permissions
Quantity Over Quality: Metrics in Solid Organ Transplantation Cross, Nicholas B.; Dittmer, Ian Cross, Nicholas B.; Dittmer, Ian Less Transplantation. 102(7):1031-1032, July 2018. In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Brett and colleagues describe their careful systematic review of the published literature on quality metrics in solid organ transplantation, but whether the use of metrics is delivering better quality care and improved outcomes is unknown because of no randomized trials. Go to Full Text of this Article
The Impact of Renal Insufficiency After Liver Transplantation Braun, Hillary J.; Ascher, Nancy L. Braun, Hillary J.; Ascher, Nancy L. Less Transplantation. 102(7):1033-1034, July 2018. In Brief In Brief Favorites PDF Get Content & Permissions In Brief: The authors provide context for renal outcomes as a predictor of posttransplant mortality in liver transplantation recipients in a commentary on VanWagner et al in this issue of Transplantation. Go to Full Text of this Article
Preemptive Kidney Transplantation: What’s the Hold Up? Gourlay, William Gourlay, William Less Transplantation. 102(7):1035-1036, July 2018. In Brief In Brief Favorites PDF Get Content & Permissions In Brief: This commentary highlights that timely referral of renal patients who may be candidates for transplantation and shorter time to complete the living donor assessment are the two potentially modifiable interventions that may increase the number of preemptive kidney transplants. Go to Full Text of this Article
Preexisting Cancer in Transplant Candidates: Time for a Change in Practice? Knoll, Greg A.; Chadban, Steven J. Knoll, Greg A.; Chadban, Steven J. Less Transplantation. 102(7):1037-1038, July 2018. In Brief In Brief Favorites PDF Get Content & Permissions In Brief: The authors wisely revisit our thoughts regarding the influence of a pretransplant malignancy on all-cause mortality, both cancer and noncancer specific and they try to identify subpopulations at worse prognosis. Go to Full Text of this Article
British Transplantation Society / Renal Association UK Guidelines for Living Donor Kidney Transplantation 2018: Summary of Updated Guidance Andrews, Peter A.; Burnapp, Lisa Andrews, Peter A.; Burnapp, Lisa Less Transplantation. 102(7):e307, July 2018. Favorites PDF Get Content & Permissions
Porcine Isolated Liver Perfusion for the Study of Ischemia Reperfusion Injury: A Systematic Review Maione, Francesca; Gilbo, Nicholas; Lazzaro, Silvia; More Maione, Francesca; Gilbo, Nicholas; Lazzaro, Silvia; Friend, Peter; Camussi, Giovanni; Romagnoli, Renato; Pirenne, Jacques; Jochmans, Ina; Monbaliu, Diethard Less Transplantation. 102(7):1039-1049, July 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: The authors summarize the methods of isolated liver perfusion (ILP) together with the parameters for evaluation of ischemia reperfusion injury. ILP is also evaluated as a model to replace liver transplantation in animals with the benefits and limitations.
Quality Metrics in Solid Organ Transplantation: A Systematic Review Brett, Kendra E.; Ritchie, Lindsay J.; Ertel, Emily; More Brett, Kendra E.; Ritchie, Lindsay J.; Ertel, Emily; Bennett, Alexandria; Knoll, Greg A. Less Transplantation. 102(7):e308-e330, July 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: Go to Full Text of this Article In Brief: Many quality metrics reported in solid organ transplantation lacks details on development and selection and future research will need to focus on transparent and objective metric development with proper testing, evaluation, and implementation in practice with involvement of patients and caregivers. Go to Full Text of this Article
Overcoming Coagulation Dysregulation in Pig Solid Organ Transplantation in Nonhuman Primates: Recent Progress Wang, Liaoran; Cooper, David K.C.; Burdorf, Lars; More Wang, Liaoran; Cooper, David K.C.; Burdorf, Lars; Wang, Yi; Iwase, Hayato Less Transplantation. 102(7):1050-1058, July 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: The authors review the updated strategies using genetic manipulations combined with immunosuppressant for overcoming thrombotic microangiopathy in pig-to-nonhuman primate organ transplant models.
Extracorporeal Photopheresis for Bronchiolitis Obliterans Syndrome After Lung Transplantation Hachem, Ramsey; Corris, Paul Hachem, Ramsey; Corris, Paul Less Transplantation. 102(7):1059-1065, July 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: Go to Full Text of this Article In Brief: The authors review the use of extracorporeal photopheresis in lung transplantation and show that it has immunomodulatory effects that provide a rationale for its use. Observational studies show improvement or stabilization in lung function decreases in the rate of lung function deterioration. Go to Full Text of this Article
Syndecan-1 Shedding Inhibition to Protect Against Ischemic Acute Kidney Injury Through HGF Target Signaling Pathway Lu, Zhihui; Song, Nana; Shen, Bo; More Lu, Zhihui; Song, Nana; Shen, Bo; Xu, XiaLian; Fang, Yi; Shi, Yiqin; Ning, Yichun; Hu, Jiachang; Dai, Yan; Ding, Xiaoqiang; Zou, Jianzhou; Teng, Jie Less Transplantation. 102(7):e331-e344, July 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: Go to Full Text of this Article In Brief: The authors investigate the role of syndecan-1 in a mouse kidney ischemia reperfusion (I/R) injury model. It is demonstrated that inhibiting I/R-induced syndecan-1 shedding may protect against ischemic acute kidney injury by potentiating the c-Met/AKT/GSK-3ß pathway. Go to Full Text of this Article
CORM-401 Reduces Ischemia Reperfusion Injury in an Ex Vivo Renal Porcine Model of the Donation After Circulatory Death Bhattacharjee, Rabindra N.; Richard-Mohamed, Mahms; Sun, Qizhi; More Bhattacharjee, Rabindra N.; Richard-Mohamed, Mahms; Sun, Qizhi; Haig, Aaron; Aboalsamh, Ghaleb; Barrett, Peter; Mayer, Richard; Alhasan, Ibrahim; Pineda-Solis, Karen; Jiang, Larry; Alharbi, Hajed; Saha, Manujendra; Patterson, Eric; Sener, Alp; Cepinskas, Gediminas; Jevnikar, Anthony M.; Luke, Patrick P.W. Less Transplantation. 102(7):1066-1074, July 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: The authors demonstrate that perfusate infused CORM-401 protects the kidney from postreperfusion injury through reduction of vascular resistance, apoptosis and necrosis in a porcine DCD model.
Tofacitinib Halts Progression of Graft Dysfunction in a Rat Model of Mixed Cellular and Humoral Rejection Rovira, Jordi; Ramírez-Bajo, María José.; Banon-Maneus, Elisenda; More Rovira, Jordi; Ramírez-Bajo, María José.; Banon-Maneus, Elisenda; Lazo-Rodríguez, Marta; Moya-Rull, Daniel; Hierro-Garcia, Natalia; Tubita, Valeria; Piñeiro, Gastón J.; Revuelta, Ignacio; Ventura-Aguiar, Pedro; Cucchiari, David; Oppenheimer, Federico; Brunet, Mercè; Campistol, Josep M.; Diekmann, Fritz Less Transplantation. 102(7):1075-1084, July 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Rovira et al report tofacitinib, a Janus kinase 3 inhibitor, reduces T and NK cell infiltration, preserves tubular and glomerular structures, and prevents the progression of allograft dysfunction in a Fisher-to-Lewis rat model of kidney transplantation.
Disruption of the Gut Microbiota With Antibiotics Exacerbates Acute Vascular Rejection Rey, Kevin; Manku, Sukhbir; Enns, Winnie; More Rey, Kevin; Manku, Sukhbir; Enns, Winnie; Van Rossum, Thea; Bushell, Kevin; Morin, Ryan D.; Brinkman, Fiona S.L.; Choy, Jonathan C. Less Transplantation. 102(7):1085-1095, July 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Disruption of mice gut microbiota, either for their entire life or only during the first 3 weeks of life, results in increased acute vascular rejection of allograft arteries due to infiltration of the media by neutrophils. Intima thickening of the arteries reflecting chronic rejection is not affected.
Cardiovascular Disease Outcomes Related to Early Stage Renal Impairment After Liver Transplantation VanWagner, Lisa B.; Montag, Samantha; Zhao, Lihui; More VanWagner, Lisa B.; Montag, Samantha; Zhao, Lihui; Allen, Norrina B.; Lloyd-Jones, Donald M.; Das, Arighno; Skaro, Anton I.; Hohmann, Samuel; Friedewald, John J.; Levitsky, Josh Less Transplantation. 102(7):1096-1107, July 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: The authors identify renal impairment as a predictor of both all-cause and cardiovascular mortality after liver transplantation.
Outcomes of Donation After Circulatory Death Liver Grafts From Donors 50 Years or Older: A Multicenter Analysis Croome, Kristopher P.; Mathur, Amit K.; Lee, David D.; More Croome, Kristopher P.; Mathur, Amit K.; Lee, David D.; Moss, Adyr A.; Rosen, Charles B.; Heimbach, Julie K.; Taner, C. Burcin Less Transplantation. 102(7):1108-1114, July 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: This multicenter study demonstrates acceptable graft and patients’ survival with utilization of donation after circulatory death (DCD) donors age = 50 if appropriate measures are employed, particularly regarding recipient characteristics at transplantation.
Higher Risk of Posttransplant Liver Graft Failure in Male Recipients of Female Donor Grafts Might Not Be Due to Anastomotic Size Disparity Lee, Kyo Won; Han, Sangbin; Lee, Sanghoon; More Lee, Kyo Won; Han, Sangbin; Lee, Sanghoon; Cha, Hyun-Hwa; Ahn, Soohyun; Ahn, Hyeon Seon; Ko, Justin Sangwook; Gwak, Mi Sook; Kim, Gaab Soo; Joh, Jae-Won; Lee, Suk-Koo; Choi, Gyu-Seong Less Transplantation. 102(7):1115-1123, July 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Posttransplant liver graft failure occurs most often in male recipients of livers from female donors and donor sex appears to be an independent factor modulating graft failure risk in male liver transplant recipients.
Deceased Donor Organ Transplantation Performed in the United States for Noncitizens and Nonresidents Delmonico, Francis L.; Gunderson, Susan; Iyer, Kishore R.; More Delmonico, Francis L.; Gunderson, Susan; Iyer, Kishore R.; Danovitch, Gabriel M.; Pruett, Timothy L.; Reyes, Jorge D.; Ascher, Nancy L. Less Transplantation. 102(7):1124-1131, July 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: The authors analyze the UNOS data regarding citizenship and residency status of all organ recipients within the USA. On top of getting current and accurate data, the authors discuss the potential deleterious consequences for US residents and the applicability to all other countries facing the same issue.
Specific Donor HLA-DR Types Correlate With Altered Susceptibility to Development of Chronic Lung Allograft Dysfunction Haynes, Lynn D.; Julliard, Walker A.; Mezrich, Joshua D.; More Haynes, Lynn D.; Julliard, Walker A.; Mezrich, Joshua D.; Leverson, Glen; Meyer, Keith C.; Burlingham, William J. Less Transplantation. 102(7):1132-1138, July 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: In a retrospective study of outcomes in 351 lung transplant recipients, the authors demonstrate that some donor HLA class II types are associated with susceptibility (especially HLA-DR15) or protection from the development of severe bronchiolitis obliterans syndrome.
Toward Systematic Screening for Persistent Hepatitis E Virus Infections in Transplant Patients Ankcorn, Michael J.; Ijaz, Samreen; Poh, John; More Ankcorn, Michael J.; Ijaz, Samreen; Poh, John; Elsharkawy, Ahmed M.; Smit, Erasmus; Cramb, Robert; Ravi, Swathi; Martin, Kate; Tedder, Richard; Neuberger, James Less Transplantation. 102(7):1139-1147, July 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Transplant recipients in the UK are at a low but significant risk of hepatitis E virus (HEV) infection and HEV-Ag detection could be an alternative to RNA detection where the goal is to identify established persistent HEV infection.
Landscape of Living Multiorgan Donation in the United States: A Registry-Based Cohort Study Henderson, Macey L.; DiBrito, Sandra R.; Thomas, Alvin G.; More Henderson, Macey L.; DiBrito, Sandra R.; Thomas, Alvin G.; Holscher, Courtenay M.; Shaffer, Ashton A.; Bowring, Mary Grace; Purnell, Tanjala S.; Massie, Allan B.; Garonzik-Wang, Jacqueline M.; Waldram, Madeleine M.; Lentine, Krista L.; Segev, Dorry L. Less Transplantation. 102(7):1148-1155, July 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: The authors used SRTR data to characterize living donors who donated more than 1 organ either simultaneously or sequentially. One hundred one cases were identified over the past 2 decades, mostly performed in a small number of centers. One donor died 2.5 years after the second donation but the cause was not recorded and overall, complete follow-up was available for none of the patients. These data are not sufficient to draw conclusions about the value of these procedures.
Solid Organ Transplantation in Patients With Preexisting Malignancies in Remission: A Propensity Score Matched Cohort Study Acuna, Sergio A.; Sutradhar, Rinku; Kim, S. Joseph; More Acuna, Sergio A.; Sutradhar, Rinku; Kim, S. Joseph; Baxter, Nancy N. Less Transplantation. 102(7):1156-1164, July 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Using a propensity score matched cohort study design, the authors report on a worse survival of organ transplant recipients with pretransplant malignancy than without. However, the increased risk, both cancer specific or not, is mainly conveyed by high risk malignancies.
Prospective Assessment of Adenovirus Infection in Pediatric Kidney Transplant Recipients Engen, Rachel M.; Huang, Meei-Li; Park, Giulia E.; More Engen, Rachel M.; Huang, Meei-Li; Park, Giulia E.; Smith, Jodi M.; Limaye, Ajit P. Less Transplantation. 102(7):1165-1171, July 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: This prospective study shows that adenovirus viremia occurs in 15% of pediatric kidney transplant recipients. It is symptomatic in half of those who are viremic and mildly symptomatic in the other half. The authors conclude that routine monitoring for adenovirus viremia in pediatric kidney transplant recipients may not be warranted.
Superior Hypertension Management in Pediatric Kidney Transplant Patients After Native Nephrectomy Brubaker, Aleah L.; Stoltz, Daniel J.; Chaudhuri, Abanti; More Brubaker, Aleah L.; Stoltz, Daniel J.; Chaudhuri, Abanti; Maestretti, Lynn; Grimm, Paul C.; Concepcion, Waldo; Gallo, Amy E. Less Transplantation. 102(7):1172-1178, July 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: This single-center retrospective analysis including 136 pediatric kidney transplant recipients suggests that native nephrectomy is associated with lower number of antihypertensive medication following transplantation. This intervention may facilitate medication compliance and improve long-term outcomes.
Impact of Willingness to Accept Hepatitis C Seropositive Kidneys Among Hepatitis C RNA-Positive Waitlisted Patients Sageshima, Junichiro; Troppmann, Christoph; McVicar, John P.; More Sageshima, Junichiro; Troppmann, Christoph; McVicar, John P.; Santhanakrishnan, Chandrasekar; de Mattos, Angelo M.; Perez, Richard V. Less Transplantation. 102(7):1179-1187, July 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: This single-center retrospective analysis in HCV+ patients suggests that willingness to accept kidney allografts from HCV + donors was associated with increased rate of transplantation, lower removal from the list and transplant outcomes comparable to those listed only for HCV- donors.
Association of Cold Ischemia Time With Acute Renal Transplant Rejection Postalcioglu, Merve; Kaze, Arnaud D.; Byun, Benjamin C.; More Postalcioglu, Merve; Kaze, Arnaud D.; Byun, Benjamin C.; Siedlecki, Andrew; Tullius, Stefan G.; Milford, Edgar L.; Paik, Julie M.; Abdi, Reza Less Transplantation. 102(7):1188-1194, July 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Prolonged cold ischemia time is associated with an increased risk of acute renal transplant rejection (ARTR) and death-censored graft loss, however older age is associated with a lower risk of ARTR.
Initiating Maintenance Dialysis Before Living Kidney Donor Transplantation When a Donor Candidate Evaluation Is Well Underway Habbous, Steven; McArthur, Eric; Dixon, Stephanie N.; More Habbous, Steven; McArthur, Eric; Dixon, Stephanie N.; McKenzie, Susan; Garcia-Ochoa, Carlos; Lam, Ngan N.; Lentine, Krista L.; Dipchand, Christine; Litchfield, Kenneth; Begen, Mehmet A.; Sarma, Sisira; Garg, Amit X. Less Transplantation. 102(7):e345-e353, July 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: This analysis using healthcare databases from 5 transplant centers in Canada confirms the difficulties in performing preemptive kidney transplants even with expedited living donor evaluation. Yet, not all the factors accounting for this observation can be promptly optimized.
Early and Late Hepatitis B Reactivation After IFN- or DAA-based Therapy of Recurrent Hepatitis C in Anti–HBc-positive Liver Transplant Recipients Tucci, Alessandra; Rizza, Stefano; Cocchis, Donatella; More Tucci, Alessandra; Rizza, Stefano; Cocchis, Donatella; Martini, Silvia; Romagnoli, Renato; Marzano, Alfredo Less Transplantation. 102(7):e354-e355, July 2018. Favorites PDF Get Content & Permissions
Belatacept and Autoimmune Adverse Events Ville, Simon; Cantarovich, Diego Ville, Simon; Cantarovich, Diego Less Transplantation. 102(7):e355-e356, July 2018. Favorites PDF Get Content & Permissions
Biomarkers and Kidney Transplant: Time for a New Paradigm? Erratum Less Transplantation. 102(7):e357, July 2018. Favorites PDF Get Content & Permissions
mTOR Inhibition and Clinical Transplantation: Heart Erratum Less Transplantation. 102(7):e358, July 2018. Favorites PDF Get Content & Permissions
Validation of the Prognostic Kidney Donor Risk Index (KDRI) Scoring System of Deceased Donors for Renal Transplantation in the Netherlands: Erratum Less Transplantation. 102(7):e359, July 2018. Favorites PDF Get Content & Permissions
New Answers to Old Conundrums: What Antibodies, Exosomes and Inflammasomes Bring to the Conversation. Canadian National Transplant Research Program International Summit Report Erratum Less Transplantation. 102(7):e360, July 2018. Favorites PDF Get Content & Permissions
