Organ Donation in Wales: Time to Reflect Moore, Richard; Thomas, Roy J.; Jones, Chris Moore, Richard; Thomas, Roy J.; Jones, Chris Less Transplantation. 102(12):1961-1962, December 2018. Favorites PDF Get Content & Permissions
Research Highlights Muller, Elmi Muller, Elmi Less Transplantation. 102(12):1962-1963, December 2018. Favorites PDF Get Content & Permissions
Doris A. Taylor, PhD, Hon DSc: Director, Regenerative Medicine Research, Director, Center for Cell and Organ Biotechnology at Texas Heart Institute and Texas A&M University Less Transplantation. 102(12):1963-1965, December 2018. Favorites PDF Get Content & Permissions
On Reporting of the Outcomes from Clinical Trials; a Call to Order Heilman, Raymond L.; Srinivas, Titte R.; Kaplan, Bruce Heilman, Raymond L.; Srinivas, Titte R.; Kaplan, Bruce Less Transplantation. 102(12):1966-1967, December 2018. Favorites PDF Get Content & Permissions
The Importance of Outcome Metrics in Allocation Policy Karp, Seth J. Karp, Seth J. Less Transplantation. 102(12):1968-1969, December 2018. Favorites PDF Get Content & Permissions
γδ T Cells in Transplantation: Friend and Foe Sullivan, Lucy C.; Shaw, Evangeline M.; Westall, Glen P. Sullivan, Lucy C.; Shaw, Evangeline M.; Westall, Glen P. Less Transplantation. 102(12):1970-1971, December 2018. Favorites PDF Get Content & Permissions
Cell Spray Transplantation of Stem Cells for Ischemic Cardiomyopathy—How Effective Are Dispersed Droplets? Ensminger, Stephan Ensminger, Stephan Less Transplantation. 102(12):1972-1973, December 2018. Favorites PDF Get Content & Permissions
Perspectives on the Optimal Genetically Engineered Pig in 2018 for Initial Clinical Trials of Kidney or Heart Xenotransplantation Cooper, David K.C.; Ezzelarab, Mohamed; Iwase, Hayato; More Cooper, David K.C.; Ezzelarab, Mohamed; Iwase, Hayato; Hara, Hidetaka Less Transplantation. 102(12):1974-1982, December 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: The authors summarize the optimal genetically-engineered pig models for preclinical studies of heart and kidney transplantation. It is suggested that not only the deletion of xenoantigenes is important, but also the additional insertion of protective human transgenes is beneficial, and may be essential.
Deciphering the Contribution of γδ T Cells to Outcomes in Transplantation McCallion, Oliver; Hester, Joanna; Issa, Fadi McCallion, Oliver; Hester, Joanna; Issa, Fadi Less Transplantation. 102(12):1983-1993, December 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: A comprehensive overview of the ?d T cell literature, focusing on the ways in which their functional heterogeneity contributes to outcomes after transplantation, and reflection upon methods to harness their beneficial properties.
Kidney Transplant in the Era of Modern Therapy for Multiple Myeloma Huskey, Janna L.; Heilman, Raymond L.; Khamash, Hasan; More Huskey, Janna L.; Heilman, Raymond L.; Khamash, Hasan; Fonseca, Rafael Less Transplantation. 102(12):1994-2001, December 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: The authors present data in order to safely and successfully transplant patients with a multiple myeloma through a close multidisciplinary approach between hematologists and transplant teams.
CXCR4 Antagonist Reduced the Incidence of Acute Rejection and Controlled Cardiac Allograft Vasculopathy in a Swine Heart Transplant Model Receiving a Mycophenolate-based Immunosuppressive Regimen Hsu, Wan-Tseng; Lin, Cheng-Hsin; Jui, Hsiang-Yiang; More Hsu, Wan-Tseng; Lin, Cheng-Hsin; Jui, Hsiang-Yiang; Tseng, Ya-Hsuan; Shun, Chia-Tung; Hsu, Ming-Chu; Wu, Kenneth Kun-Yu; Lee, Chii-Ming Less Transplantation. 102(12):2002-2011, December 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: Go to Full Text of this Article In Brief: The authors demonstrate that the augmentation of conventional MMF plus corticosteroids with a CXCR4 antagonist is potentially effective in attenuation of acute rejection in a pig heat transplantation model. Go to Full Text of this Article
IL-17A Is Critical for CD8+ T Effector Response in Airway Epithelial Injury After Transplantation Zhang, Ruochan; Fang, Huihui; Chen, Rongjuan; More Zhang, Ruochan; Fang, Huihui; Chen, Rongjuan; Ochando, Jordi C.; Ding, Yaozhong; Xu, Jiangnan Less Transplantation. 102(12):e483-e493, December 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Using murine orthotopic allogeneic trachea or lung transplants, Zhang et al demonstrate critical roles for ROR ?t, IL-17 and CD8+ T cells in mediating airway epithelial injury and lung allograft rejection.
Cell Spray Transplantation of Adipose-derived Mesenchymal Stem Cell Recovers Ischemic Cardiomyopathy in a Porcine Model Mori, Daisuke; Miyagawa, Shigeru; Yajima, Shin; More Mori, Daisuke; Miyagawa, Shigeru; Yajima, Shin; Saito, Shunsuke; Fukushima, Satsuki; Ueno, Takayoshi; Toda, Koichi; Kawai, Kotoe; Kurata, Hayato; Nishida, Hiroyuki; Isohashi, Kayako; Hatazawa, Jun; Sawa, Yoshiki Less Transplantation. 102(12):2012-2024, December 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: The authors investigate a new method for cell therapy to treat ischemic cardiomyopathy and demonstrate that the spray method implantation of mesenchymal stem cells improves recovery of cardiac function in a porcine infarction model.
Recipient Age and Mortality After Liver Transplantation: A Population-based Cohort Study Gil, Eunmi; Kim, Jong Man; Jeon, Kyeongman; More Gil, Eunmi; Kim, Jong Man; Jeon, Kyeongman; Park, Hyejeong; Kang, Danbee; Cho, Juhee; Suh, Gee Young; Park, Jinkyeong Less Transplantation. 102(12):2025-2032, December 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: Go to Full Text of this Article In Brief: The authors examined mortality risk for a large cohort of liver transplant recipients between 2007 and May 2016 covered by the Korean National Health Insurance system (n = 9415). Both costs and mortality were significantly increased in the cohort over 70 years old. Go to Full Text of this Article
Quantifying the Effect of Transplanting Older Donor Livers Into Younger Recipients: The Need for Donor-recipient Age Matching Bittermann, Therese; Goldberg, David S. Bittermann, Therese; Goldberg, David S. Less Transplantation. 102(12):2033-2037, December 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Using the Organ Procurement and Transplantation Network Registry (primary liver transplants performed from 2002–2015), the authors of this retrospective study assessed the differential impact of using older donors in younger as opposed to older recipients.
Revascularization Time in Liver Transplantation: Independent Prediction of Inferior Short- and Long-term Outcomes by Prolonged Graft Implantation Buchholz, Bettina M.; Gerlach, Undine A.; Chandrabalan, Vishnu V.; More Buchholz, Bettina M.; Gerlach, Undine A.; Chandrabalan, Vishnu V.; Hodson, James; Gunson, Bridget K.; Mergental, Hynek; Muiesan, Paolo; Isaac, John R.; Roberts, Keith J.; Mirza, Darius F.; Perera, M. Thamara P. R. Less Transplantation. 102(12):2038-2055, December 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: The authors have identified an association between reperfusion time and graft and patient outcomes in liver transplantation. Whether this is causal or the consequence of unmeasured confounders will require further study.
Impact of Early Initiated Everolimus on the Recurrence of Hepatocellular Carcinoma After Liver Transplantation Rodríguez-Perálvarez, Manuel; Guerrero, Marta; Barrera, Lydia; More Rodríguez-Perálvarez, Manuel; Guerrero, Marta; Barrera, Lydia; Ferrín, Gustavo; Álamo, Jose M.; Ayllón, María D.; Artacho, Gonzalo Suarez; Montero, José L.; Briceño, Javier; Bernal, Carmen; Padillo, Javier; Marín-Gómez, Luis M.; Pascasio, Juan M.; Poyato, Antonio; Gómez-Bravo, Miguel A.; De la Mata, Manuel Less Transplantation. 102(12):2056-2064, December 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: The authors of this retrospective study compare the outcome of liver transplant patients with hepatocellular carcinoma (HCC) who receive everolimus or standard immunosuppression without observing significant differences of HCC recurrence rates.
Range and Consistency of Outcomes Reported in Randomized Trials Conducted in Kidney Transplant Recipients: A Systematic Review Sautenet, Bénédicte; Tong, Allison; Chapman, Jeremy R.; More Sautenet, Bénédicte; Tong, Allison; Chapman, Jeremy R.; Warrens, Anthony N.; Rosenbloom, David; Wong, Germaine; Gill, John; Budde, Klemens; Rostaing, Lionel; Marson, Lorna; Josephson, Michelle A; Reese, Peter P.; Pruett, Timothy L.; Evangelidis, Nicole; Craig, Jonathan C. Less Transplantation. 102(12):2065-2071, December 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: This review confirms that while mortality and graft related outcomes are frequently reported in trials in kidney transplantation, surrogate outcomes, life-threatening complications and patient-reported outcome are uncommon, suggesting the need to establish core outcomes to improve clinical decision-making.
Donor-specific Antibody Surveillance and Graft Outcomes in Pediatric Kidney Transplant Recipients Engen, Rachel M.; Park, Giulia E.; Schumacher, Cooper S.; More Engen, Rachel M.; Park, Giulia E.; Schumacher, Cooper S.; Gimferrer, Idoia; Warner, Paul; Finn, Laura S.; Weiss, Noel S.; Smith, Jodi M. Less Transplantation. 102(12):2072-2079, December 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: In 103 kidney transplant children recipients of a first kidney, dnDSA detected for cause is associated with an increased risk of ABMR and graft failure which was not the case when dnDSA are detected on a routine basis.
Population Health, Ethnicity, and Rate of Living Donor Kidney Transplantation Reed, Rhiannon D.; Sawinski, Deirdre; Shelton, Brittany A.; More Reed, Rhiannon D.; Sawinski, Deirdre; Shelton, Brittany A.; MacLennan, Paul A.; Hanaway, Michael; Kumar, Vineeta; Long, Dustin; Gaston, Robert S.; Kilgore, Meredith L.; Julian, Bruce A.; Lewis, Cora E.; Locke, Jayme E. Less Transplantation. 102(12):2080-2087, December 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: The factor which has a negative impact on living donation is investigated and the rate of living donation is significantly lower in areas with more comorbid disease, poorer socioeconomic status, and in areas with higher prevalence of minorities.
Changes in Utilization and Discard of HCV Antibody-Positive Deceased Donor Kidneys in the Era of Direct-Acting Antiviral Therapy Bowring, Mary G.; Kucirka, Lauren M.; Massie, Allan B.; More Bowring, Mary G.; Kucirka, Lauren M.; Massie, Allan B.; Ishaque, Tanveen; Bae, Sunjae; Shaffer, Ashton A.; Garonzik Wang, Jacqueline; Sulkowski, Mark; Desai, Niraj; Segev, Dorry L.; Durand, Christine M. Less Transplantation. 102(12):2088-2095, December 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: The authors compare the willingness of listed patients to accept an HCV+ kidney, and the current use and discard rates of such kidneys, during 2 time periods, before the use of HCV direct antiviral therapy and since then. Willingness to accept and current acceptance increased, but surprisingly the discard rate of HCV+ kidneys also increased which leaves some hope for improvement.
Donating Another Person’s Kidney: Avoiding the Discard of Organs by Retransplantation Veale, Jeffrey L.; Lum, Erik L.; Cowan, Nicholas G.; More Veale, Jeffrey L.; Lum, Erik L.; Cowan, Nicholas G.; Wong, Melissa; Skovira, Kelly A.; Armijo, Mauri J.; Danovitch, Gabriel M.; Mone, Thomas D. Less Transplantation. 102(12):2096-2100, December 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Retransplantation of previously transplanted kidneys can be performed successfully, overcoming the immunological, logistical, and technical barriers, and should be considered in the face of the current organ shortage.
Muscle Mass and Mortality After Cardiac Transplantation Bibas, Lior; Saleh, Eli; Al-Kharji, Samah; More Bibas, Lior; Saleh, Eli; Al-Kharji, Samah; Chetrit, Jessica; Mullie, Louis; Cantarovich, Marcelo; Cecere, Renzo; Giannetti, Nadia; Afilalo, Jonathan Less Transplantation. 102(12):2101-2107, December 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: In 161 heart transplant recipients, psoas muscle area, a marker of frailty measured with CT scan, is an independent predictor of mortality and major morbidity.
Maximizing Utilization in Pancreas Transplantation: Phenotypic Characteristics Differentiating Aggressive From Nonaggressive Transplant Centers Serrano, Oscar Kenneth; Vock, David M.; Dunn, Ty B.; More Serrano, Oscar Kenneth; Vock, David M.; Dunn, Ty B.; Kandaswamy, Raja; Finger, Erik B. Less Transplantation. 102(12):2108-2119, December 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Aggressiveness center practice patterns using higher risk pancreas donors and recipients does not negatively affect outcomes, and this effect is likely mediated through efficiencies gained with the increased transplant volumes at these centers.
Impact of the Current Versus the Previous Diagnostic Threshold on the Outcome of Patients With Borderline Changes Suspicious for T Cell–mediated Rejection Diagnosed on Indication Biopsies McRae, Michael; Bouchard-Boivin, François; Béland, Stéphanie; More McRae, Michael; Bouchard-Boivin, François; Béland, Stéphanie; Noël, Réal; Côté, Isabelle; Lapointe, Isabelle; Lesage, Julie; Latulippe, Eva; Riopel, Julie; Santoriello, Dominick; Husain, Syed A.; Désy, Olivier; Houde, Isabelle; Batal, Ibrahim; De Serres, Sacha A. Less Transplantation. 102(12):2120-2125, December 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: In order to evaluate the most appropriate threshold of t and i in the borderline changes suspicious for T cell acute rejection Banff category, the authors compare various outcomes according the severity of histological lesions on indication biopsies. Overall, patients with t1i0 and no rejection share the same prognosis while those with =t1i1 have a worse prognosis.
Therapeutic Human IgG Preparations Contain Mixture of HLA Antibodies to Native HLA Antigens and Cryptic Epitopes With Little Clinical Significance Mangiola, Massimo; Marrari, Marilyn; Ensor, Christopher; More Mangiola, Massimo; Marrari, Marilyn; Ensor, Christopher; Spycher, Martin O.; Berger, Mel; Zeevi, Adriana Less Transplantation. 102(12):2126-2132, December 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Thirty-two lots from 2 different commercial preparations of IVIg contain non-complement binding DSA with a MFI greater that 2000 MFI in about 2/3 of cases, the majority of which was directed against denatured antigens.
How Far Can We Expand Donor Age Criteria for Pancreas Transplantation? Mensink, Jacobus W.; de Boer, Jacob D.; Kopp, Wouter H.; More Mensink, Jacobus W.; de Boer, Jacob D.; Kopp, Wouter H.; Braat, Andries E. Less Transplantation. 102(12):e494, December 2018. Favorites PDF Get Content & Permissions
The Authors’ Reply Proneth, Andrea; Geissler, Edward K.; Schlitt, Hans J.; More Proneth, Andrea; Geissler, Edward K.; Schlitt, Hans J.; Farkas, Stefan A. Less Transplantation. 102(12):e495, December 2018. Favorites PDF Get Content & Permissions
Donor Hypothermia and Heart Transplantation Schnuelle, Peter; Benck, Urs; Krämer, Bernhard K. Schnuelle, Peter; Benck, Urs; Krämer, Bernhard K. Less Transplantation. 102(12):e495-e496, December 2018. Favorites PDF Get Content & Permissions
A 2018 Reference Guide to the Banff Classification of Renal Allograft Pathology: Erratum Less Transplantation. 102(12):e497, December 2018. Favorites PDF Get Content & Permissions
