ARTICLE: PDF OnlyPERIPHERAL BLOOD LEUCOCYTE CHANGES DURING HUMAN RENAL ALLOGRAFT REJECTIONPARKER, JOAN R.1; MOWBRAY, J. F.Author Information Department of Surgery, Guy's Hospital Medical School, London, S.E. 1, and Department of Experimental Pathology, St. Mary's Hospital Medical School, London, W. 2, England 1Provincial Blood Grouping Laboratory, Medical School, Observatory, Cape Province, South Africa. The work herein described is in partial fulfillment of the requirements for the Ph.D. degree at the University of London. Transplantation: March 1971 - Volume 11 - Issue 3 - p 201-209 Free Abstract An investigation of the effect of transplanted renal allografts on human blood mononuclear leucocytes has revealed a significant increase in the rate of ribonucleic acid (RNA) synthesis in peripheral blood mononuclear cells during clinically diagnosed rejection episodes. This increased metabolic activity was shown to be related to a simultaneous increase in the number of “atypical mononuclear cells” present in the circulating blood at this time. These cells are morphologically distinct from lymphoid cells and resemble immature cells of the myeloid series. The appearance of these cells during rejection episodes suggests that they are associated with the immune reaction, rather than with a nonspecific event, and that they are of value for the early diagnosis of rejection episodes in clinical renal transplantation. © Williams & Wilkins 1971. All Rights Reserved.