Protocols for global ischemia/reperfusion (I/R) via heterotopic heart transplantation into the abdominal aortae of recipient rats. (A) Protocols for the warm and cold I/R groups, which were the same except for the temperature during ischemia, i.e., 37°C and 4°C, respectively. (B) Protocol for the effects of a broad-spectrum caspase inhibitor and volume-regulatory chloride channel inhibitors on global I/R injury.