Solid Organ Transplantation in Singapore Kee, Terence; Shridhar Ganpathi, Iyer; Sivathasan, Cumaraswamy; More Kee, Terence; Shridhar Ganpathi, Iyer; Sivathasan, Cumaraswamy; Kong, Sally; Premaraj, Jeyaraj; Anantharaman, Vathsala Less Transplantation. 102(9):1397-1400, September 2018. Favorites PDF Get Content & Permissions
Research Highlights Issa, Fadi Issa, Fadi Less Transplantation. 102(9):1401-1402, September 2018. Favorites PDF Get Content & Permissions
Placebo-induced Immunosuppression: A Game Changer? van Gelder, Teun van Gelder, Teun Less Transplantation. 102(9):1402-1403, September 2018. Favorites PDF Get Content & Permissions
Hans W. Sollinger, MD, PhD Sollinger, Hans W. Sollinger, Hans W. Less Transplantation. 102(9):1403-1404, September 2018. Favorites PDF Get Content & Permissions
Crowd Sourcing for Organs: A Social Dilemma Baboolal, Kesh Baboolal, Kesh Less Transplantation. 102(9):1405-1406, September 2018. Favorites PDF Get Content & Permissions
Caspase Inhibition: Optimizing Grafts for Transplantation Detelich, Danielle; Yeh, Heidi; Uygun, Korkut Detelich, Danielle; Yeh, Heidi; Uygun, Korkut Less Transplantation. 102(9):1407-1408, September 2018. In Brief In Brief Favorites PDF Get Content & Permissions In Brief: The authors summarize the protective roles of caspase inhibitors during kidney preservation. Targeting at caspase-dependent cell death pathway by administering graft-protective intervention during ex vivo cold storage may improve the graft function. Go to Full Text of this Article
T-bet or IFNγ Neutralization for Blocking Islet Allograft Rejection? Le Moine, Alain Le Moine, Alain Less Transplantation. 102(9):1409-1410, September 2018. In Brief In Brief Favorites PDF Get Content & Permissions In Brief: A commentary discussing the potential implications of the findings that T-bet deficiency abrogates the ability to acutely reject allogeneic islet allografts whereas IFN?-deficiency does not. Go to Full Text of this Article
Pregnancy and Heart Transplantation: Giving Birth After a New Life Potena, Luciano; Moriconi, Veronica; Presta, Elvira Potena, Luciano; Moriconi, Veronica; Presta, Elvira Less Transplantation. 102(9):1411-1412, September 2018. In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Unlike pregnancy in kidney transplant recipients, the project of giving birth in heart transplant recipients obviously carries a more serious potential risk if the heart is rejected. The authors clearly delineate what has to be done regarding the information and precautions to be taken in order to successfully carry on this important project. Go to Full Text of this Article
Minimally Invasive Transplantation of Primary Human Hepatocyte Inserts that Facilitate Vascularization Domen, Jos Domen, Jos Less Transplantation. 102(9):1413-1414, September 2018. In Brief In Brief Favorites PDF Get Content & Permissions In Brief: The author discusses the obstacles of cell-based approaches for supporting and improving liver function. The bioengineered microencapsulate primary human hepatocytes in hydrogels demonstrate its clinical potentials. Go to Full Text of this Article
Systematic Reviews and Meta-analyses in Transplantation: Challenges and Pitfalls? Wong, Germaine; Sharma, Ankit; Teixeira-Pinto, Armando; More Wong, Germaine; Sharma, Ankit; Teixeira-Pinto, Armando; Howell, Martin Less Transplantation. 102(9):1415-1418, September 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: Go to Full Text of this Article In Brief: The authors present a timely review of the statistical considerations involved in systematic reviews and meta-analyses. Special attention to common pitfalls is emphasized. Go to Full Text of this Article
iChoose Kidney for Treatment Options: Updated Models for Shared Decision Aid Gander, Jennifer C.; Basu, Mohua; McPherson, Laura; More Gander, Jennifer C.; Basu, Mohua; McPherson, Laura; Garber, Michael D.; Pastan, Stephen O.; Manatunga, Amita; Arriola, Kimberly Jacob; Patzer, Rachel E. Less Transplantation. 102(9):e370-e371, September 2018. Favorites PDF Get Content & Permissions
The First Kidney Transplant in Ireland O’Donovan, Fiona C. O’Donovan, Fiona C. Less Transplantation. 102(9):e372, September 2018. Favorites PDF Get Content & Permissions
Critical Appraisal of International Clinical Practice Guidelines in Kidney Transplantation Using the Appraisal of Guidelines for Research and Education II Tool: A Systematic Review O'Donoghue, Katriona Jane Marie; Reed, Rhiannon D.; Knight, Simon R.; More O'Donoghue, Katriona Jane Marie; Reed, Rhiannon D.; Knight, Simon R.; O'Callaghan, John M.; Ayaz-Shah, Anam A.; Hassan, Sevda; Weissenbacher, Annemarie; Morris, Peter J.; Pengel, Liset H.M. Less Transplantation. 102(9):1419-1439, September 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Clinical Practice Guidelines in kidney transplantation are appraised in this systematic review looking at quality and interrater variability. Overall, most CPGs lacked key aspects of methodological robustness and transparency, which leaves room for significant improvement.
Belatacept in Solid Organ Transplant: Review of Current Literature Across Transplant Types Perez, Caroline P.; Patel, Neha; Mardis, Caitlin R.; More Perez, Caroline P.; Patel, Neha; Mardis, Caitlin R.; Meadows, Holly B.; Taber, David J.; Pilch, Nicole A. Less Transplantation. 102(9):1440-1452, September 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: This review summarizes the efficacy and safety of de novo and conversion use of belatacept after solid organ transplantation, including challenges associated with chronic monthly infusions, effects on treatment adherence, associated costs, and ongoing clinical trials exploring innovative immunosuppressive strategies.
Coagulation Defects in the Cirrhotic Patient Undergoing Liver Transplantation Parker, Arabesque; Karvellas, Constantine J. Parker, Arabesque; Karvellas, Constantine J. Less Transplantation. 102(9):1453-1458, September 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: This review provides an overview of the pathophysiology of hemostasis in liver disease, highlights challenges in laboratory monitoring, and offers recommendations for management of bleeding and thrombosis in the liver transplant recipient.
Diagnosis, Pathophysiology and Experimental Models of Chronic Lung Allograft Rejection Gauthier, Jason M.; Ruiz-Pérez, Daniel; Li, Wenjun; More Gauthier, Jason M.; Ruiz-Pérez, Daniel; Li, Wenjun; Hachem, Ramsey R.; Puri, Varun; Gelman, Andrew E.; Kreisel, Daniel Less Transplantation. 102(9):1459-1466, September 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Chronic rejection is the Achilles’ heel of modern lung transplantation, and the authors review the pathological hallmarks of chronic rejection, recent insights gained from both clinical and basic science research, and the current state of animal models of chronic lung rejection.
Advances on CD8+ Treg Cells and Their Potential in Transplantation Bézie, Séverine; Anegon, Ignacio; Guillonneau, Carole Bézie, Séverine; Anegon, Ignacio; Guillonneau, Carole Less Transplantation. 102(9):1467-1478, September 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: An expert review on the controversial FoxP3-CD8+ and FoxP3+CD8+ Tregs, their immunobiology, potential role in tolerance, and their potential for clinical trials in solid organ transplantation and GvHD.
Defining Outcomes for β-cell Replacement Therapy in the Treatment of Diabetes: A Consensus Report on the Igls Criteria From the IPITA/EPITA Opinion Leaders Workshop Rickels, Michael R.; Stock, Peter G.; de Koning, Eelco J.P.; More Rickels, Michael R.; Stock, Peter G.; de Koning, Eelco J.P.; Piemonti, Lorenzo; Pratschke, Johann; Alejandro, Rodolfo; Bellin, Melena D.; Berney, Thierry; Choudhary, Pratik; Johnson, Paul R.; Kandaswamy, Raja; Kay, Thomas W.H.; Keymeulen, Bart; Kudva, Yogish C.; Latres, Esther; Langer, Robert M.; Lehmann, Roger; Ludwig, Barbara; Markmann, James F.; Marinac, Marjana; Odorico, Jon S.; Pattou, François; Senior, Peter A.; Shaw, James A.M.; Vantyghem, Marie-Christine; White, Steven Less Transplantation. 102(9):1479-1486, September 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: A new consensus statement proposes that successful islet and pancreas transplant function be categorized as either “optimal” or “good.” Unsuccessful islet and pancreas transplant function can be categorized as “marginal” or “failed.”
Caspase Inhibition During Cold Storage Improves Graft Function and Histology in a Murine Kidney Transplant Model Nydam, Trevor L.; Plenter, Robert; Jain, Swati; More Nydam, Trevor L.; Plenter, Robert; Jain, Swati; Lucia, Scott; Jani, Alkesh Less Transplantation. 102(9):1487-1495, September 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: The authors investigate the efficacy of caspase inhibitor on improvement of graft function and attenuation of tubular cell apoptosis in a mouse kidney transplantation model (in vivo) as well as mouse tubular cells (in vitro).
Differential Impact of T-bet and IFNγ on Pancreatic Islet Allograft Rejection Besançon, Alix; Demir, Zeynep; Goncalves, Tania; More Besançon, Alix; Demir, Zeynep; Goncalves, Tania; Valette, Fabrice; Panafieu, Emilie; Chatenoud, Lucienne; You, Sylvaine Less Transplantation. 102(9):1496-1504, September 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Besançon et al report that T-bet-deficient recipients spontaneously accept allogeneic pancreatic islets, whereas IFN?-deficient recipients retain their ability to reject due to expression of compensatory effector mechanisms comprising increased Eomes, cytolytic molecules, and TNFa.
Early TLR4 Blockade Attenuates Sterile Inflammation-mediated Stress in Islets During Isolation and Promotes Successful Transplant Outcomes Chang, Charles A.; Murphy, Kayla; Kane, Robert R.; More Chang, Charles A.; Murphy, Kayla; Kane, Robert R.; Lawrence, Michael C.; Naziruddin, Bashoo Less Transplantation. 102(9):1505-1513, September 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: TLR4 blockade with TAK-242, a small molecular inhibitor, protects islets from sterile inflammation-mediated stress in a syngeneic transplant model using a marginal mass of islets transplanted intraportally into mice with streptozotocin-induced diabetes.
Macroporous Dual-compartment Hydrogels for Minimally Invasive Transplantation of Primary Human Hepatocytes Seale, Nailah; Ramaswamy, Suvasini; Shih, Yu-Ru; More Seale, Nailah; Ramaswamy, Suvasini; Shih, Yu-Ru; Verma, Inder; Varghese, Shyni Less Transplantation. 102(9):e373-e381, September 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: The authors investigate the therapeutic potential of a vascularizable dual compartment hydrogel system for primary hepatocytes subcutaneous implantation in a mouse model. It is demonstrated that such a cell transplant device can be used as a minimally invasive ectopic liver accessory for improving the function.
Long-term Outcomes and Risk Factors After Adult Living Donor Liver Transplantation Imai, Daisuke; Yoshizumi, Tomoharu; Sakata, Kazuhito; More Imai, Daisuke; Yoshizumi, Tomoharu; Sakata, Kazuhito; Ikegami, Toru; Itoh, Shinji; Harada, Noboru; Motomura, Takashi; Toshima, Takeo; Mano, Yohei; Soejima, Yuji; Maehara, Yoshihiko Less Transplantation. 102(9):e382-e391, September 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: In this large single-center retrospective study, the authors describe the long-term mortality and risk factors following adult living donor liver transplantation highlighting the importance of malignancies, rejection, and bile duct stenosis.
Minimizing Risk Associated With Older Liver Donors by Matching to Preferred Recipients: A National Registry and Validation Study Haugen, Christine E.; Thomas, Alvin G.; Garonzik-Wang, Jacqueline; More Haugen, Christine E.; Thomas, Alvin G.; Garonzik-Wang, Jacqueline; Massie, Allan B.; Segev, Dorry L. Less Transplantation. 102(9):1514-1519, September 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: The authors have updated a previous study validating an approach to optimal use of livers from older donors.
Predicting Liver Allograft Discard: The Discard Risk Index Rana, Abbas; Sigireddi, Rohini R.; Halazun, Karim J.; More Rana, Abbas; Sigireddi, Rohini R.; Halazun, Karim J.; Kothare, Aishwarya; Wu, Meng-Fen; Liu, Hao; Kueht, Michael L.; Vierling, John M.; Sussman, Norman L.; Mindikoglu, Ayse L.; Miloh, Tamir; Galvan, N. Thao N.; Cotton, Ronald T.; O’Mahony, Christine A.; Goss, John A. Less Transplantation. 102(9):1520-1529, September 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: An algorithm is presented that might identify discard of donor livers and be used to optimize allocation sequences and inform policy development.
Survival and Quality of Life Impact of a Risk-based Allocation Algorithm for Deceased Donor Kidney Transplantation Calisa, Vaishnavi; Craig, Jonathan C.; Howard, Kirsten; More Calisa, Vaishnavi; Craig, Jonathan C.; Howard, Kirsten; Howell, Martin; Alexander, Stephen; Chadban, Steven J.; Clayton, Philip; Lim, Wai H.; Kanellis, John; Wyburn, Kate; Johnson, David W.; McDonald, Stephen P.; Opdam, Helen; Chapman, Jeremy R.; Yang, Jean; Wong, Germaine Less Transplantation. 102(9):1530-1537, September 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: This simulation using Australian registry data underscores the challenges of deceased donor kidney allocation systems, showing that a new risk-based matching allocation algorithm would be associated with increased graft and patient survival, benefiting younger in detriment of older candidates.
The Effect of Pregnancy on the Long-term Risk of Graft Loss, Cardiovascular Disease, and Death in Kidney Transplanted Women in Norway: A Retrospective Cohort Study Majak, Guri B.; Reisæter, Anna Varberg; Weedon-Fekjær, Harald; More Majak, Guri B.; Reisæter, Anna Varberg; Weedon-Fekjær, Harald; Henriksen, Tore; Michelsen, Trond M. Less Transplantation. 102(9):e391-e396, September 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: The authors have evaluated the impact of pregnancy on long-term kidney transplant outcome and found kidney transplanted women with pregnancies have a low risk of subsequent graft loss or death.
A New Life: Motherhood After Heart Transplantation. A Single-center Experience and Review of Literature Macera, Francesca; Occhi, Lucia; Masciocco, Gabriella; More Macera, Francesca; Occhi, Lucia; Masciocco, Gabriella; Varrenti, Marisa; Frigerio, Maria Less Transplantation. 102(9):1538-1544, September 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Pregnancy is a rare event after heart transplantation. The authors describe the results of pregnancy in 12 patients with a clear description of the risks and of the special care to be given to these patients.
Conversion to Belatacept in Maintenance Kidney Transplant Patients: A Retrospective Multicenter European Study Darres, Amandine; Ulloa, Camillo; Brakemeier, Susanne; More Darres, Amandine; Ulloa, Camillo; Brakemeier, Susanne; Garrouste, Cyril; Bestard, Oriol; Del Bello, Arnaud; Sberro Soussan, Rebecca; Dürr, Michael; Budde, Klemens; Legendre, Christophe; Kamar, Nassim Less Transplantation. 102(9):1545-1552, September 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: This European retrospective study shows that conversion to belatacept from a calcineurin inhibitor-based regimen is associated with an average 6 mL/min improvement in eGFR. Conversion less than 3 months after transplant for delayed or poor function is associated with greater increases in eGFR but a 33% acute rejection rate.
The Changing Epidemiology of Posttransplant Lymphoproliferative Disorder in Adult Solid Organ Transplant Recipients Over 30 Years: A Single-center Experience Peters, Anthea C.; Akinwumi, Michael S.; Cervera, Carlos; More Peters, Anthea C.; Akinwumi, Michael S.; Cervera, Carlos; Mabilangan, Curtis; Ghosh, Sunita; Lai, Raymond; Iafolla, Marco; Doucette, Karen; Preiksaitis, Jutta K. Less Transplantation. 102(9):1553-1562, September 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: This single-center study of PTLD over 30 years shows that the incidence of PTLD has decreased mostly because of a decrease of early PTLD in EBV seropositive but not seronegative recipients showing a lack of impact of viral load monitoring.
Evolution of Glycemic Control and Variability After Kidney Transplant Aouad, Leyla J.; Clayton, Philip; Wyburn, Kate R.; More Aouad, Leyla J.; Clayton, Philip; Wyburn, Kate R.; Gracey, David M.; Chadban, Steven J. Less Transplantation. 102(9):1563-1568, September 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Using three periods of continuous glycemic monitoring in 24 kidney transplant recipients, the authors highlight a very frequent and variable dysglycemia, especially in the afternoon and evening and in patients with previous diabetes and posttransplant diabetes mellitus.
Specific Immunity to Cytomegalovirus in Pediatric Cardiac Transplantation Jacobsen, Marianne C.; Manunta, Maria D.I.; Pincott, Emma S.; More Jacobsen, Marianne C.; Manunta, Maria D.I.; Pincott, Emma S.; Fenton, Matthew; Simpson, Gavin L.; Klein, Nigel J.; Burch, Michael Less Transplantation. 102(9):1569-1575, September 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Pediatric heart transplant patients with active CMV viral replication under a preemptive strategy have increased CMV specific immune responses and CD8+CD57+GB+ cells that have the potential to cause endothelial injury that might cause cardiac vasculopathy.
Incidence, Risk Factors, and Outcomes of Clostridium difficile Infections in Kidney Transplant Recipients Li, George J.; Trac, Justin; Husain, Shahid; More Li, George J.; Trac, Justin; Husain, Shahid; Famure, Olusegun; Li, Yanhong; Kim, S. Joseph Less Transplantation. 102(9):1576-1581, September 2018. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: The authors show that the incidence rate of clostridium difficile infection (CDI) in kidney transplant recipients is 0.64 cases/100 person-years. Risks include duration of antibiotics, deceased donor, and acute rejection for which CDI is an independent risk factor.
Secondhand Hypertrophy: A Rare Case of Genetically Based Pathology Developing Within a Transplanted Heart Parker, William A. E.; Sinha, Akanksha; Ramshaw, Helen J.; More Parker, William A. E.; Sinha, Akanksha; Ramshaw, Helen J.; D’Arcy, Emma K.; Braidley, Peter C.; Al-Mohammad, Abdallah Less Transplantation. 102(9):e397-e398, September 2018. Favorites PDF Get Content & Permissions
Optimal Culture Methods and Microbial Contamination During Kidney Ex Vivo Normothermic Perfusion Shahrestani, Sara; Hameed, Ahmer; Hitos, Kerry; More Shahrestani, Sara; Hameed, Ahmer; Hitos, Kerry; Pleass, Henry; Hawthorne, Wayne J. Less Transplantation. 102(9):e398-e399, September 2018. Favorites PDF Get Content & Permissions
The Authors’ Reply Phillips, Benedict Lyle; Chandak, Pankaj; Uwechue, Raphael; More Phillips, Benedict Lyle; Chandak, Pankaj; Uwechue, Raphael; van Nispen tot Pannerden, Claire; Hemsley, Caroline; Callaghan, Chris Less Transplantation. 102(9):e399-e400, September 2018. Favorites PDF Get Content & Permissions
