Risk of Breakthrough SARS-CoV-2 Infections in Adult Transplant Recipients : Transplantation

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Risk of Breakthrough SARS-CoV-2 Infections in Adult Transplant Recipients

Qin, Caroline X. BS1; Moore, Linda W. PhD2; Anjan, Shweta MD3; Rahamimov, Ruth MD4; Sifri, Costi D. MD5; Ali, Nicole M. MD6; Morales, Megan K. MD7; Tsapepas, Demetra S. PharmD8; Basic-Jukic, Nikolina MD, PhD9; Miller, Rachel A. MD10; van Duin, David MD, PhD11; Santella, Robert N. MD12; Wadei, Hani M. MD13; Shah, Pali D. MD14; Gage, Nikki RN15; Malinis, Maricar MD16; Aslam, Saima MD, MS17; Todesco, Eve PhD18; Werbel, William A. MD14; Avery, Robin K. MD14; Segev, Dorry L. MD, PhD1

Author Information

1 Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

2 Department of Surgery, Houston Methodist Hospital, Houston, TX.

3 Division of Infectious Disease, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL.

4 Department of Nephrology and Hypertension, Rabin Medical Center, Petah-Tikva, Israel.

5 Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA.

6 Transplant Institute, NYU Langone Health, New York, NY.

7 Division of Infectious Diseases, Department of Internal Medicine, Virginia Commonwealth University Health, Richmond, VA.

8 Department of Surgery, Columbia University College of Physicians and Surgeons, New York, NY.

9 Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Clinical Hospital Centre Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia.

10 Division of Infectious Diseases, Department of Medicine, Duke University, Durham, NC.

11 Division of Infectious Diseases, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC.

12 Avera Medical Group Nephrology, Avera McKennan Hospital and University Health Center, Sioux Falls, SD.

13 Department of Transplant, Mayo Clinic, Jacksonville, FL.

14 Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.

15 Virginia Transplant Center at Henrico Doctors’ Hospital, Henrico, VA.

16 Department of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT.

17 Division of Infectious Diseases & Global Public Health, Department of Medicine, University of California San Diego, San Diego, CA.

18 Sorbonne UniversitĂ©, INSERM, Institut Pierre Louis d’EpidĂ©miologie et de SantĂ© publique (iPLESP), APHP, HĂ´pital PitiĂ©-SalpĂªtrière, Paris, France.

Received 14 July 2021. Revision received 19 July 2021.

Accepted 20 July 2021.

All authors participated in conception or design of the work or the acquisition, analysis, or interpretation of data for the work; drafting the work or revising it critically for important intellectual content; and gave final approval of the version to be published. D.L.S. agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

D.L.S. received honoraria for consulting and speaking from Sanofi, Novartis, CSL Behring, Jazz Pharmaceuticals, Veloxis, Mallinckrodt, and Thermo Fisher Scientific. R.K.A has received study/grant support from Aicuris, Astellas, Chimerix, Merck, Oxford Immunotec, Qiagen, and Takeda/Shire. S.A. received grant support from the Cystic Fibrosis Foundation, received consulting honoraria from Merck and Gilead, and was an unpaid consultant for BioMX. The other authors declare no conflicts of interest.

This research was made possible with the generous support of the Ben-Dov family. This work was supported by grant number K24AI144954 (D.L.S.) from the National Institute of Allergy and Infectious Diseases and by grant gSAN-201C0WW from the Transplantation and Immunology Research Network of the American Society of Transplantation (W.A.W.).

The analyses described here are the responsibility of the authors alone and do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.

Correspondence: Dorry L. Segev, MD, PhD, Department of Surgery, Johns Hopkins University School of Medicine, 2000 E Monument St., Baltimore, MD 21205. ([email protected]).

Transplantation 105(11):p e265-e266, November 2021. | DOI: 10.1097/TP.0000000000003907
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Abstract

It is well established at this point that solid organ transplant recipients (SOTRs) have substantially diminished antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines.1,2 The correlation of this suboptimal antibody response to disease susceptibility is clinically important but poorly understood. In this multicenter study, we estimated the breakthrough infection rates after SARS-CoV-2 mRNA vaccination in SOTRs and compared them with rates reported in the general population.

This study was approved by our institutional review board. We identified transplant centers that were able to provide information about the number of SOTRs who had been fully vaccinated, developed breakthrough infections after vaccination, developed breakthrough infections and were hospitalized, and developed breakthrough infections and died, through personal inquiries among colleagues and corresponding author contacts from PubMed and Scopus searches. Data were collected as summary counts; no patient-level data were provided or studied. Breakthrough infections were defined per Centers for Disease Control and Prevention criteria (≥14 d after completing all recommended vaccine doses).

Among a total of 18 215 fully vaccinated SOTRs at 17 transplant centers, there were 151 breakthrough infections (0.83%), 87 with associated hospitalization (0.48%) and 14 with associated death (0.077%). Mortality among SOTRs with breakthrough infection was 14 of 151 (9.3%). Center-level breakthrough infection rates varied from 0.23% to 2.52% (Table 1).

TABLE 1. - Center-level summary of SARS-CoV-2 breakthrough infections
No. of vaccinated (N = 18 215) No. of infected (N = 151) No. of hospitalized (N = 87) No. of dead (N = 14) Breakthrough infection rate (%)
870 2 1 0 0.23
1640 7 5 1 0.43
2350 13 7 3 0.55
459 3 1 0 0.65
3457 24 14 1 0.69
1432 10 6 1 0.70
133 1 1 1 0.75
891 7 1 1 0.79
629 5 3 0 0.79
1072 10 3 0 0.93
904 9 2 0 1.00
350 4 3 1 1.14
2292 27 23 1 1.18
847 11 8 4 1.30
360 6 0 0 1.67
212 4 3 0 1.89
317 8 6 0 2.52
No., number; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.

Of 101 million fully vaccinated adults in the United States through April 30, 2021, Centers for Disease Control and Prevention reported 10 262 breakthrough infections (0.0102%), 995 with associated hospitalization (0.00099%) and 160 with associated death (0.00016%).3 Compared with the general population, SOTRs in our study had an 82-fold higher risk of breakthrough infection and 485-fold higher risks of breakthrough infection with associated hospitalization and death.

There are a number of limitations to this study. First, enumerating the population of fully vaccinated SOTRs is challenging, and, in most cases, these numbers should be viewed as estimates. That said, even if there were an estimation error as extreme as twice as many vaccinated SOTRs, the risk of breakthrough infections would still be 41-fold higher than the general population. Second, despite potential ascertainment bias in SOTRs, many centers expressed to us the possibility of not fully capturing all SARS-CoV-2 infections in their SOTR population: patients could have been seen at other hospitals, seen by nontransplant providers at the same hospital, or tested positive in the community without informing their transplant centers. As such, the number of breakthrough infections is likely an underestimate.

Our main finding is that, compared with the general population, SOTRs have lower protection from SARS-CoV-2 infection after vaccination. This emphasizes the clinical relevance of a growing literature describing decreased immunogenicity in this population and highlights the critical need to better understand and improve vaccine response.4,5 For now, it is clear that SOTRs should continue to practice all recommended safety precautions such as masks and distancing, household contacts should be vaccinated if at all possible, priority should be given to vaccination pretransplantation, and other interventions for potential protection should be explored.

However, another important question is whether SOTRs benefit from vaccination: rather than comparing vaccinated SOTRs with the vaccinated general population, it is also important to compare vaccinated SOTRs with unvaccinated SOTRs. Any comparisons are inherently limited by temporal and treatment bias, but it does seem that standard vaccination provides protection: the majority of SOTRs produce some antibodies, the breakthrough infection rate in our study is lower than reported de novo infection rates as high as 5% in unvaccinated SOTRs,6 and the mortality rate from breakthrough infections in our study is lower than the commonly reported mortality of 20.5% from de novo infections in unvaccinated SOTRs.7 Finally, there is growing evidence that boosters will ultimately improve vaccine effectiveness even further. As such, vaccination is critically important and should be prioritized in all SOTRs.

REFERENCES

1. Boyarsky BJ, Werbel WA, Avery RK, et al. Antibody response to 2-dose SARS-CoV-2 mRNA vaccine series in solid organ transplant recipients. JAMA. 2021;325:2204–2206.
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3. CDC COVID-19 Vaccine Breakthrough Case Investigations Team. COVID-19 vaccine breakthrough infections reported to CDC—United States, January 1–April 30, 2021. MMWR Morb Mortal Wkly Rep. 2021;70:792–793.
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