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Letters to the Editor

Significance of Offspring Donors on Long-term Survival in Adult Living Donor Liver Transplantation: Asian Experience

Ho, Cheng-Maw MD, PhD1; Hu, Rey-Heng MD, PhD1; Lee, Po-Huang MD, PhD1

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doi: 10.1097/TP.0000000000003351
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To the Editor:

We rejoice in reading the article by Dagan et al1 published in Transplantation and noticed the recipient outcome discrepancy between offspring versus nonoffspring donor source in living donor liver transplantation. The major ethnicity of the cohort was White or Hispanic. Here we provided Asian experience. The Institutional Review Board of National Taiwan University Hospital, Taipei, Taiwan approved the study (NTUH REC: 201410006RINA).

From January 2000 to July 2019, 405 patients received living-related adult liver transplantation in National Taiwan University Hospital including a total of 276 offspring donors (156 males) and 129 nonoffspring donors. Survival between offspring versus nonoffspring donor (P = 0.975) and male offspring versus female offspring donor (P = 0.690) was not significantly different (Figure 1, log-rank test). The hazard ratio of living donor source (offspring versus nonoffspring) impacting overall survival was 0.916 (0.597-1.480). Therefore, from Asian perspective, compared with other living-related donors, living donors derived from offspring did not pose hazard to liver transplant recipients.

Kaplan-Meier overall survival of liver recipients. A, Offspring vs nonoffspring donors. B, Male offspring vs female offspring donors.


1. Dagan A, Choudhury RA, Yaffe H, et al. Offspring versus nonoffspring to parent living donor liver transplantation: does donor relationship matter? Transplantation. 2020; 104:996–1002doi:10.1097/TP.0000000000002977
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