On the cover
Different mechanisms are synergistically used by CD8+ Tregs to inhibit immune responses in the context of transplantation. CD8+Tregs can take advantage of cell contact interactions during allogeneic recognition to modulate APCs toward a tolerogenic function through PD-1, CTLA-4, GITR, ILT3, and ILT4 membrane molecules. Concomitantly with this local action, secretion of cytokines, such as IL-34, IL-10, FGL-2, or TGFbeta, and chemokines spreads the tolerance to diverse targets, inhibiting effector cells, converting new regulatory cells and recruiting support. Besides, expression of CD122, CD25, or CD38 receptors by CD8+Tregs impoverish environment of immune response mediators.
Séverine Bézie,1,2,3 Ignacio Anegon,1,2,3 and Carole Guillonneau1,2,3
1Centre de Recherche en Transplantation et Immunologie, INSERM1064, Université de Nantes, Nantes, France.
2Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France.
3LabEx IGO “Immunotherapy, Graft, Oncology”, Nantes, France.