On the cover
In this H&E-stained section of CMV pneumonitis, infected pneumocytes show both nuclear and cytoplasmic enlargement, their nuclei containing large basophilic to amphophilic inclusions, several of which are surrounded by typical, clear halos. Cytoplasmic inclusions are smaller and less sharply defined, again often with a surrounding zone of cytoplasmic clearing. These appear most evident in the uppermost infected cell in this photomicrograph. The lung tissue shows chronic inflammation, foamy histiocytes and reactive hyperplasia of type II pneumocytes as evidence of lung injury.
Authors: Randall T. Hayden, MD,1 Mary K. Klassen-Fischer, MD,2 Camille N. Kotton, MD3
1 St. Jude Children’s Research Hospital, Memphis, TN
2 Joint Pathology Center, Silver Spring, MD
3 Massachusetts General Hospital, Harvard Medical School, Boston, MA