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doi: 10.1097/01.tp.0000533783.25877.f4
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Quantum dots as tools to probe the role of self-antigen display in generating tolerance

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Figure

Hess et al [1] use quantum dots (green) to control the density of self-antigen displayed at the molecular scale. This approach provides a tool to probe the role of ligand number and density during tolerance induction in mice. The precisely displayed self-molecules are internalized by antigen-presenting cells (clear) in lymph nodes that polarize inflammatory T cells (orange) to regulatory T cells (developing green region). Precision display of donor-derived peptides on nanoparticles may be useful in promoting tolerance for transplantation. Authors: Christopher M. Jewell, PhD, Krystina L. Hess, Demin Liu.

References:

[1] Krystina L. Hess,a Eunkeu Oh,b,c Lisa H. Tostanoski,a James I. Andorko,a Kimihiro Susumu,b,c Jeffrey R. Deschamps,d Igor L. Medintz,d and Christopher M. Jewell.a,e,f,g Engineering Immunological Tolerance Using Quantum Dots to Tune the Density of Self-Antigen Display. Adv Funct Mater. 2017;27(22). pii: 1700290.

a Fischell Department of Bioengineering University of Maryland 8228 Paint Branch Drive, College Park, MD 20742, USA.

b Optical Sciences Division, Code 5600 U.S. Naval Research Laboratory 4555 Overlook Ave, SW, Washington, DC 20375, USA.

c Sotera Defense Solutions, Inc. Columbia, MD 21046, USA.

d Center for Bio/Molecular Science and Engineering Code 6900 U.S. Naval Research Laboratory 4555 Overlook Ave SW, Washington, DC 20375, USA.

e Department of Microbiology and Immunology University of Maryland Medical School 685 West Baltimore Street, HSF-I Suite 380, Baltimore, MD21201, USA.

f Marlene and Stewart Greenebaum Cancer Center 22 South Greene Street, Baltimore, MD 21201, USA.

e U.S. Department of Veterans Affairs 10 N Green Street, Baltimore, MD 21201, USA.

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