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The Study of Relationship between Serum Levels of Soluble VEGF Receptor-1 With Delayed Graft Function After Kidney Transplantation

Nikoueinejad, Hassan1; Akbari, Hossein2; Einollahi, Behzad1

doi: 10.1097/

1Nephology & Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran (Islamic Republic of); 2Biostatictics Department, Kashan University of Medical Sciences, Kashan, Iran (Islamic Republic of).

Introduction: Delayed graft function (DGF) is a transplant complication which means needing dialysis throughout the first week after transplantation. This study aimed to ascertain the relationship between soluble VEGF receptor-1, as an immunomodulatory factor, and DGF after transplantation.

Materials and Methods: This case control study was done in a 6-month period among 2 groups of 58-member of transplanted patients with and without DGF. The control group included the patients who were operated in 2015 and didn’t show DGF symptoms. Then, sFlt-1 level in all blood samples was measured by Elisa.

Results: Serum sFlt-1 levels were significantly higher in DGF group compared to those in control group (P ≤ 0.001). SFlt-1 serum levels significantly affect on DGF (P < 0.001) in such a way that it increases the risk of DGF (OR = 1.1).

Conclusion: This study showed a significant relationship between sFlt-1 and DGF. Therefore, plasma levels of sFlt-1 may be used as a diagnostic tool to determine the risk of DGF.

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