Live donor nephrectomy is considered to be a safe, low-risk procedure, fully implemented in many transplant centers worldwide. There are many different surgical techniques for this procedure, and preference differs between centers.1,2 Although the traditional open technique is still used, minimally invasive procedures should be recommended as the criterion standard, because morbidity is reduced and quality of life improved.3-5 Modifications to the laparoscopic technique have been introduced, including the retroperitoneoscopic approach (retroperitoneoscopic donor nephrectomy), hand-assistance (hand-assisted laparoscopic donor nephrectomy/hand-assisted retroperitoneoscopic donor nephrectomy), and robot-assisted approach as well as the single incision laparoscopic donor nephrectomy (laparoendoscopic single-site surgery [LESS]). More recently, the first cases of natural orifice transluminal endoscopic surgery live donor nephrectomy have been reported, with transvaginal kidney extraction.6-8 With the introduction of these techniques, a great number of studies, including randomized controlled trials (RTCs), have been performed to assess their value, safety and efficacy. Still, there does not seem to be 1 technique that evidently stands out from the rest, and preferences vary among surgeons and centers (as seen in a recent survey among kidney transplant surgeons, Kortram et al, unpublished). Overall, complication rates are low and mortality occurs only sporadically.9,10 However, if a healthy donor is not well informed and experiences complications related to the procedure anger and distress may occur, negatively affecting the outcome for this patient as well as the living donation program. Therefore, donors must be well educated during the informed consent process. A key condition for the successful employment of donor education and informed consent is the availability of a complete overview of the specific details and risks of the operative techniques.
Little research has been performed regarding the specific contents of the informed consent procedure, and there are no well-designed studies on how donors experience the informed consent and the educational process.11 Available evidence is quite subjective, and if anything, suggests that some donors report feeling misinformed, in a single incidence to such a degree that the donor felt the transplant team had withheld the truth about possible complications, long-term results and recipient outcome.12 On the other hand, providing more information does not necessarily improve donors' comprehension of details and risks of the procedure.13-15
The current project has 2 major objectives. First, to provide a systematic review of all available evidence on informed consent including all information regarding short term outcome of minimally invasive live donor nephrectomy focusing on the incidence of individual complications. Second, to conduct a meta-analysis comparing the different procedures for live donor nephrectomy and complications. By creating a clear overview of the incidence of complications and (serious) adverse events, evidence-based information can be provided to potential donors, thereby further optimizing our educational and informed consent process for the live donor nephrectomy.
MATERIALS AND METHODS
All aspects of the Cochrane Handbook for Interventional Systematic Reviews were followed, and the study was written according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement16 for Randomized Controlled Trials and the Meta-analysis of Observations Studies in Epidemiology guidelines17 for observational studies. The initial review protocol was registered in the PROSPERO database with number CRD4201404170 (www.crd.york.ac.uk/PROSPERO/).
Literature Search Strategy
A comprehensive search was performed with the help of a biomedical information specialist on September 24, 2014, and updated on March 8, 2016, in Embase, Medline OvidSP, Web-of-Science, PubMed, CENTRAL, and Google Scholar (Figure 1). No date limits were used. Search strings for each database are provided in Appendix 1, no other limits were applied during the search. During screening, only articles written in English were included to prevent any misinterpretations of data. All references were screened by 2 independent reviewers (K.K., F.J.M.F.D.). If any discrepancies occurred, a third investigator was consulted (J.N.M.I.). Study selection was accomplished through 2 phases. During the first phase, titles and abstracts were reviewed for relevance, and full-text articles were obtained. Published abstracts were included if they contained detailed information regarding complications. During the second phase, full-text articles were reviewed. Case reports, commentaries, and letters were excluded. Survey studies and studies describing results from national databases were excluded to prevent double inclusion of donors. Studies mentioning short-term complications after minimally invasive live donor nephrectomy were eligible for inclusion. If a full text article corresponding to a published meeting abstract was available, the abstract was disregarded. The same strategy was used for preliminary results of which definitive results were also available. If data was unclear or pooled for different techniques or indications, the authors were contacted to provide source data. Authors were also contacted when study cohorts of 2 or more publications seemed to overlap. If no response was obtained after 2 reminders, articles were excluded if data were pooled for different nephrectomy indications, or if the classic open technique was included in their cohort. In some articles, with evident overlapping cohorts, inclusion was based on a number of criteria. Preferably, the most recent publication or the largest cohort of patients was included. However, in some cases, a dated publication contained more details, and it was therefore decided to include the article with the greatest evidential value. If operative techniques were pooled, articles were included in the systematic review but not in the meta-analysis. Systematic reviews and meta-analyses were carefully screened for already published/background information but were not included in the data analysis process. All references of included full text articles were manually scrutinized to ensure that no relevant articles were missed.
All articles were used for the systematic review part of this project; only those that compared (or mentioned, within 1 cohort) 2 or more different minimally invasive live donor nephrectomy techniques were included in the meta-analysis.
Data Extraction and Critical Appraisal
Data extraction was performed by 2 authors (K.K., F.J.M.F.D.). Again, if any discrepancies occurred, consensus was reached after consulting a third investigator (J.N.M.I.). Data were collected on study design, population, operative technique, procedural details, and complications. A list of all possible complications was created before the start of data extraction, and if complications came up that were not included, these were added to the checklist. All intraoperative and postoperative complications and conversions were scored, as well as mortality. Conversions from LESS to multiport laparoscopy or a hand-assisted procedure or from pure laparoscopy/retroperitoneoscopy to hand-assisted were not scored in this analysis. If an article only described specific complications, all other complications were scored as “unknown.” If however the description of complications was detailed (for instance split to minor and major) but some “common” complications were not listed in an article, it was assumed these did not occur in that specific population and were scored as “zero.” Less frequently mentioned complications like (but not limited to) testicular pain and thigh numbness were scored as unknown. Mortality was scored as “none” or the number of fatalities, when this was literally stated. It was scored as “none assumed” when for instance “no (other) major complications occurred,” or when no donors were missing in follow-up data. All other cases were scored as “unknown.” A number of other outcome measures were scored, namely, operative time, estimated blood loss, warm ischemia time, length of stay, readmissions, length of convalescence, pain score, analgesic requirement, quality of life, and costs.
The level of evidence of each article included in the meta-analysis was established using the Grades of Recommendation, Assessment, Development and Evaluation tool.18 The Grades of Recommendation, Assessment, Development and Evaluation approach defines the quality of a body of evidence by consideration of risk of bias (methodological quality), directness of evidence, heterogeneity, precision of effect estimates and risk of publication bias (Figure S1, SDC, https://links.lww.com/TP/B308).
For the systematic review, individual complications were presented as absolute values and percentages. Continuous factors were provided in means and range.
A meta-analysis was performed using Review Manager version 5.3 (The Nordic Cochrane Center, Copenhagen, Denmark). Random effects models were used to account for possible clinical heterogeneity. Results were presented in forest plots with risk ratios (RR). Overall effects were determined using the Z-test, and results were presented in RRs. Ninety-five percent confidence intervals (CI) of these values were given, and P values less than 0.05 were considered statistically significant. Heterogeneity between studies was assessed by 3 methods. First, a Tau2 test and a χ2 test were conducted for statistical heterogeneity, with P less than 0.1 being considered statistically significant. In addition, I2 statistics were used to assess clinical heterogeneity, using a cut-off point of 35%. The number of donors in each study group weighted group means. Sensitivity analyses were performed for all outcome measures per comparison, first isolating only randomized trials, then excluding all retrospective studies. Studies with substantially more weight than others were also left out to assess different effects.
Of 2168 unique articles identified in the search, 205 fell within the scope of our predetermined search. However, there were substantial issues with 20 of these publications, that is, evidently overlapping cohorts, no specification of complications (ie, only overall percentages or grades) or pooled data for different nephrectomy indications. Five authors provided us with source data, and the other articles were excluded according to the criteria stated in the methods section. A total of 190 articles remained for the systematic review.19-208 There were a great number of publications that addressed 2 or more operative techniques but pooled complications. Two authors provided us with source data, and the other articles were excluded from the meta-analysis part of this review. Forty-one remained for inclusion in the meta-analysis. Figure S1 (SDC, https://links.lww.com/TP/B308) depicts the flowchart of the literature search.
The included articles originated from transplant centers worldwide. A table providing an overview of the number of included articles per country is included as Table S1 (SDC, https://links.lww.com/TP/B308).
Part 1—Systematic Review of Complications After Minimally Invasive Live Donor Nephrectomy
The studies comprised a total of 32.038 live donor nephrectomies. Table 1 shows the distribution of these donors over the different techniques.
For this part of the review, complications were not divided over the different operative techniques. The purpose was to provide an overview of which complications occur and in which frequency.
Conversion to a traditional open technique was mentioned in 160 articles (84%). The overall conversion rate was 1.1% (Table 2). The reason for conversion could not be determined in all cases; reasons were provided in 288 of a total of 316 conversions (91%). Elective conversions for adhesions, vascular anomalies or failure to progress were scored, although these were not considered to be complications. Conversions for bleeding or injury to other organs were also scored as intraoperative complications.
Table 2 provides an overview of all encountered complications and their incidence. There were many different definitions for intraoperative bleeding. Some authors regard it as a complication only if total blood loss exceeded 500 mL, whereas others set the limit at 300 mL. Some studies only listed bleeding as a complication when an additional intervention (ie, extra clip, suture or even conversion) was necessary and some authors did not specify at all. The need for blood transfusion was stated in 168 articles. Injury to other organs was stated in most articles; however, the action taken to repair this remained unclear in the majority thereof. Table 3 sums up the postoperative complications. The reported complications vary between studies. Although some authors report every adverse event from nausea to severe complications requiring surgical reintervention, others only mention specific types of or major complications.
Mortality within 30 days is very rare after live donor nephrectomy. Of the 190 included studies, mortality was reported in 65 (34%, N = 16 604 nephrectomies). In 77 additional articles (8512 nephrectomies), it was assumed that no mortality occurred based on complication rates and follow up. In the remaining 46 articles (24%, 6922 nephrectomies), the occurrence of mortality could not be reliably deduced. In the remaining population of 27 816, only 3 deaths were reported, adding up to an overall reported mortality rate after live donor nephrectomy of 0.01%.
A total of 165 surgical reinterventions were reported (0.6%). However, as with mortality, not every article clearly stated it; in 27 articles, reinterventions were not mentioned (N = 3.522 procedures). In addition, 4% of studies (N = 6, 12 cases) that did mention reoperations did not specify the indication therefor, and some other studies provided indications for some, but not all reinterventions (N = 14 cases). Whether reoperation was done via laparoscopy or laparotomy was unclear in the majority of studies. Most reoperations were due to bleeding or to evacuate a hematoma (N = 61, 37%). Small bowel obstruction due to internal or port-side hernia, or entrapment in a suture was the reason for reintervention in 26 cases (16%). Other indications for reintervention were wound infection or dehiscence (9), bowel injury (7), fascial dehiscence (7), splenectomy (5), appendectomy (4), orchidectomy due to torsion or ischemia (3), chylous ascites (3), pancreatic injury (2), retrieval of corpus alienum (2), abscess drainage (1), bladder injury (1), ovariectomy (1), perforated duodenal ulcer (1), vocal cord injury (1). In addition, 5 laparotomies were performed due to abdominal pain, but no abnormalities were encountered during surgery.
Other Outcome Measures
Intraoperative parameters were described in nearly all articles. Unfortunately, operative time, warm ischemia time, blood loss, length of stay, and duration of convalescence were provided in means and medians, as was the visual analog scale for postoperative pain. Because the majority of data was given in means (80%), those in medians were disregarded. Table 3 provides an overview of these extra parameters. Convalescence was defined differently in the included articles, ranging from return to daily activities to full physical function. These definitions were combined. Analgesic use, although described with fair regularity, was documented in many different ways, regarding drugs, dosage or days or even hours of use. Overall costs were not often reported, but if so, these varied enormously. The broad spectrum of inclusion dates and countries may very well account for this.
Forty-one articles were included in the meta-analysis. Comparisons were made between pure laparoperitoneoscopic and retroperitoneoscopic procedures and hand-assisted procedures, laparoscopic procedures and retroperitoneoscopic procedures, multiport and single-port procedures, and all of these together versus mini-open donor nephrectomy. Two retrospective, small-populated studies comparing the robotic technique with any of the other techniques were found in our search and 1 RCT. Unfortunately, complications in the RCT were only mentioned in Clavien-Dindo scales, and the individual complications could not be determined.209 This technique was therefore left out of the meta-analysis.
The main finding was that there were only few significant differences between the minimally invasive techniques.
Nineteen articles compared laparoperitoneoscopic and/or retroperitoneoscopic procedures with and without hand assistance, 3 RCTs,30,64,99 4 prospective,43,65,69,208 and 11 retrospective studies.38,41,54,92,116,117,139,151,152,177,179 A total of 777 procedures were performed with hand assistance, and 1465 without hand assistance, but because not all studies mentioned every outcome, total numbers vary per outcome measure. Conversion rate (1.5% vs 2.1%), and overall intraoperative (6.2% versus 5.7%) and postoperative (9.9% vs 10.3%) complication rates and surgical reinterventions (0.6% vs 0.7%) were comparable between the 2 groups. The only difference, although not statistically significant, found between these 2 techniques was intraoperative bleeding (defined as every bleeding mentioned by the author that exceeded “normal expected blood loss”), which was more frequently encountered after hand-assisted procedures (4.0 vs 3.9%; RR, 1.52; 95% CI, 0.95-2.43; P = 0.08) (Figure 2).
Laparoscopic Versus Retroperitoneoscopic Donor Nephrectomy
Seven articles compared laparoscopic with retroperitoneoscopic techniques, 2 RCTs,64,99 2 prospective,65,132 and 3 retrospective studies.41,152,163 A total of 311 procedures were retroperitoneoscopic, 1159 laparoscopic. Conversion (1.6 vs 2.0%), overall intraoperative (4.5 versus 5.6%) and postoperative complications (9.6 vs 12.2%) were again comparable between techniques. None of the individual intraoperative or postoperative complications showed statistically significant differences.
Multiport Versus Single-Port Donor Nephrectomy
Ten studies were identified comparing single-port with multiport procedures, 3 RCTs,27,107,149 1 prospective study,194 and 6 retrospective series.20,31,47,144,183,205 In total, 764 single port procedures were compared with 1214 laparoscopic procedures. Conversions were rare in these studies; only 2 occurred (0.1%), both in multiport donor nephrectomies, of which 1 was elective and 1 emergent due to bleeding. Intraoperative (0.9% in both groups) and postoperative (6.5% vs 5.2%) complications were again comparable, as were reinterventions (0.1% vs 0.9%). Postoperative pain was slightly more often described after LESS donor nephrectomies (2.7% vs 0.8%; RR, 3.56; 95% CI, 0.90-14.11; P = 0.07), other pulmonary complications (ie, pleural effusion, atelectasis, respiratory distress, pulmonary edema, or hypoxia) were more frequently reported after LESS donor nephrectomy (1.5% vs 0%; RR, 7.51; P = 0.03; 95% CI, 1.25-44.94).
Mini-Open Versus Laparoscopic Donor Nephrectomy
All articles comparing the mini-open technique with either 1 of the endoscopic techniques (ie, laparoperitoneoscopic, retroperitoneoscopic, with or without hand assistance) with the exception of single port donor nephrectomies were included in this comparison. There was 1 study that compared retroperitoneoscopic procedures to mini-open procedures, and 7 additional studies were identified comparing mini-open donor nephrectomies to laparoscopic ones. A total of 323 mini-open procedures were compared with 288 endoscopic procedures. This group comprised 3 RCTs85,133,210 and 5 prospective studies.50,115,128,195,198 Intraoperative complications were more frequently seen in laparoscopic procedures (8.2% vs 3.4%; RR, 2.45; 95% CI, 1.13-5.35; P = 0.02) (0.99-1.08; P= 0.1) (Figure 3).
This difference was mostly based on intraoperative organ damage, which demonstrated a trend in favor of open procedures (0% vs 2.8%; RR, 5.18; 95% CI, 0.91-29.35; P = 0.06) (Figure S2, SDC, https://links.lww.com/TP/B308). When sensitivity analysis was performed and only RCTs were included, the significant difference/trend disappeared (P = 0.09 and 0.1, respectively).
Overall postoperative complication rate was comparable, but nonetheless much higher than described for the other techniques (17% vs 23%). The design of the included studies, only RCTs and prospective series, might account for this finding. The incidence of pneumonia was significantly higher after open procedures (6.3% vs 3.3%; RR, 2.48; 95% CI, 1.05-5.87; P = 0.04) (Figure 4).
However, when performing sensitivity analysis, this difference was largely based on 1 study. When this group was left out of the forest plot analysis, results were quite comparable between procedures (2.0% vs 1.3%; RR, 1.32; P = 0.73 for pneumonia). Pneumothorax was not more often seen after either procedure; 0.6% for mini-open procedures (n = 1) and 1% for scopic procedures (n = 2). The surgical reintervention rate was comparable 0.6% for mini-open procedures versus 1.8% for scopic ones, but this difference was not statistically significant.
All in all, none of the used minimally invasive techniques for live donor nephrectomy stand out from the rest.
Our study is, to the best of our knowledge, the first to extensively score all complications after minimally invasive live donor nephrectomies and compare outcomes of all different techniques. A great number of minimally invasive live donor nephrectomies were included from different countries all over the world. There was no significant heterogeneity encountered in the included studies. Short-term complication rates were comparable between different techniques currently used for live donor nephrectomy, and not one of the techniques stood out from the rest. In the included studies, the pure laparoscopic approach was used in the majority of cases (57.4%). This may not be an adequate portrait of the current situation, in which the hand-assisted approach is favored in many cases.1 It is possible that some authors did indeed use hand assistance, but did not explicitly mention this in their article. No statistically significant differences were found in this meta-analysis comparing laparoscopic donor nephrectomies with and without hand assistance. The overall postoperative complication rate found in the systematic review part of our study (7.0%) is lower than the complication rates found in some of the meta-analyses (12.2% for retroperitoneoscopic techniques when compared with laparoscopic techniques and 23% for laparoscopic procedures when compared with mini-open procedures, which, in turn, had 17% complications). This may imply under reporting of complications in the systematic review part, which mainly consisted of retrospective case series. Complications were mentioned, but were not always the main outcome measure of the study. In the meta-analyses, only those studies that compared 2 or more techniques were included, and the focus was on complications in most studies. Conversions (316 overall) were described in a total of 160 articles. Unfortunately, complications were not specified for converted and nonconverted donors in most studies, so whether the conversion itself had any negative influence on the postoperative course or convalescence period remains unknown.
If we would adhere to our national guideline, according to which only those complications with an incidence of greater than 1% or those with severe consequences have to be disclosed to patients undergoing any surgical procedure,211 we would only be obliged to mention intraoperative and postoperative bleeding, conversion, wound infection (and possibly overall infectious complications), and ileus. In addition, the possibility of a reintervention and mortality should be mentioned, regardless of their incidence. However, is this really enough to ensure that a potential living kidney donor is optimally prepared and able to make a well-informed decision? Rare complications like damage to other organs, or cardiovascular events may or may not necessary have “severe consequences,” so should these be mentioned or not? Also, even though many other complications are also infrequent, and may not have significant medical consequences, they may be very relevant for donors. Prolonged pain, testicular complaints, neuropathies can be quite disconcerting to a donor who has no idea these adverse events are in fact quite “normal”.
This systematic review and meta-analysis has a number of significant limitations. None of the articles provided a complete overview of all complications, events and consequences. Some focused on intraoperative complications, others on specific postoperative complications. Conversion was mentioned in most, whereas mortality was actually mentioned in only 31% of the articles. The overall quality of reported data was quite low, and it was interesting to see the differences in portraying complications and adverse events.
Most studies are retrospective case series, some prospective and only 16 included studies were RTCs. The definition of complications in general, and especially individual complications, is bound to vary. Not every surgeon considers every adverse event to be a complication, and results are presented in that light. Overall, major complications were more often reported than minor complications, possibly leading to an underestimation of the latter. Even the definitions of frequently encountered and considered “standard” complications like bleeding or wound infection varies among authors. Some specify bleeding as the need for transfusion, or a specific amount of blood loss, but often (especially intraoperative) bleeding is not defined. When bowel or splenic injuries were encountered, it was often not stated whether resection was necessary. In addition, less frequently encountered complications like testicular complaints or thigh numbness were not mentioned in many articles, raising the question whether they did not occur, or were not reported. Overall complications rates varied greatly between different studies, and it is to be expected that complications are underreported.
Second, even though we have used all available channels to obtain as much unique data as possible, we were still dependent on the quality of published studies. Many studies included donor nephrectomies using different operative techniques, but pooled their complication data. We were able to obtain split data for a small number of these. In the majority of cases, data were no longer available or no response from the authors was received. For this reason, a number of studies could not be included in the meta-analysis, resulting in a smaller population for analysis. In addition, we had to exclude a number of studies presenting pooled data for different nephrectomy indications (other than kidney donation). Reversely, even though we applied strict exclusion criteria for overlapping cohorts, a small number of donors will inevitably have been analyzed in more than 1 included cohort.
Mortality after live donor nephrectomy is a catastrophic complication that is rarely reported. The largest cohort addressing donor mortality is reported by Segev et al,9 who found 25 donor deaths within 90 days after 80 347 live donor nephrectomies (0.03%). These were United States donors, after conventional open donor nephrectomy as well as minimally invasive procedures, and donor death was established by checking the Social Security Death Master File. Cause of death was not reported, and even though a matched cohort of nonoperated adults demonstrated lower mortality rates, this mortality rate of 0.03% cannot, with entire certainty, be attributed to live donor nephrectomy alone. In our systematic review, a reported mortality rate of 0.01% was found. Whether this is an under or overestimate remains unclear. Based on the available literature, we do know that donor deaths still occur, and that vascular complications are often not published.212,213 We therefore used strict criteria during data extraction. Mortality was scored when it was literally stated, or when the authors stated that “no complications” or no “major complications” occurred. In addition, if follow-up data were presented and none of the donors were missing, it was concluded that they had not died. Using these criteria, mortality was scored as inconclusive in 48 articles. If no deaths would have occurred in these populations, overall mortality rate would be 0.01%. Thus, we state that the actual mortality rate after live donor nephrectomy will be in the range of 0.01% to 0.1%.
Our article presents an extensive overview of different outcome measures, with emphasis on complication rates after minimally invasive live donor nephrectomy. Even though there is a risk of publication bias due to the number of included procedures, this overview will still provide quite a representable situation of current clinical practice. Based on these results, we may state that all used techniques for minimally invasive live donor nephrectomy are safe and associated with low risks of complications and an even lower risk of mortality. This allows the transplant surgeon to choose this technique with which he or she is most comfortable, and which best suits the intended donor. This form of tailormade live donor nephrectomy fits perfectly into the current trend of shared elective surgical decision making.
The authors thank WM Bramer, biomedical information specialist, for his help in conducting the systematic literature search. The authors also thank the 5 authors that provided their source data to be included in this review.
1. Klop KW, Dols LF, Kok NF, et al. Attitudes among surgeons towards live-donor nephrectomy: a European update. Transplantation
2. Lennerling A, et al. Living organ donation practices in Europe. Transplantation
3. Janki S, Dor FJ, IJzermans JN. Surgical aspects of live kidney donation: an updated review. Front Biosci (Elite Ed)
4. Nanidis TG, Antcliffe D, Kokkinos C, et al. Laparoscopic versus open live donor nephrectomy in renal transplantation: a meta-analysis. Ann Surg
5. Wilson CH, Sanni A, Rix DA, et al. Laparoscopic versus open nephrectomy for live kidney donors. Cochrane Database Syst Rev
6. Allaf ME, Singer A, Shen W, et al. Laparoscopic live donor nephrectomy with vaginal extraction: initial report. Am J Transplant
7. Pietrabissa A, Abelli M, Spinillo A, et al. Robotic-assisted laparoscopic donor nephrectomy with transvaginal extraction of the kidney. Am J Transplant
8. Kaouk JH, Khalifeh A, Laydner H, et al. Transvaginal hybrid natural orifice transluminal surgery robotic donor nephrectomy: First clinical application. Urology
9. Segev DL, Muzaale AD, Caffo BS, et al. Perioperative mortality and long-term survival following live kidney donation. JAMA
10. Ratner LE, Sandoval PR. When disaster strikes: death of a living organ donor. Am J Transplant
11. Kortram K, Lafranca JA, IJzermans JN, et al. The need for a standardized informed consent procedure in live donor nephrectomy: a systematic review. Transplantation
12. Gordon EJ. Living organ donors' stories: (unmet) expectations about informed consent, outcomes, and care. Narrat Inq Bioeth
13. Fellner C. Renal transplantation and the living donor: decision and consequences. Psychother Psychosom
14. Fellner CH, Marshall JR. Kidney donors—the myth of informed consent. Am J Psychiatry
15. Valapour M. The live organ donor's consent: is it informed and voluntary? Transplant Rev (Orlando)
16. Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol
17. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA
18. Brozek JOA, Schünemann H, GRADEpro Computer Program 3.6 for Windows ed.
19. Abrahams HM, Freise CE, Kang SM, et al. Technique, indications and outcomes of pure laparoscopic right donor nephrectomy. J Urol
20. Afaneh C, Aull MJ, Gimenez E, et al. Comparison of laparoendoscopic single-site donor nephrectomy and conventional laparoscopic donor nephrectomy: donor and recipient outcomes. Urology
21. Afaneh C, Ramasamy R, Leeser DB, et al. Is right-sided laparoendoscopic single-site donor nephrectomy feasible? Urology
22. Ahearn AJ, Posselt AM, Kang SM, et al. Experience with laparoscopic donor nephrectomy among more than 1000 cases: low complication rates, despite more challenging cases. Arch Surg
23. Alberts V, et al. Fast track hand-assisted laparoscopic donor nephrectomy: a randomized clinical trial. Transplantation
24. Alcaraz A, Rosales A, Guirado L, et al. Early experience of a living donor kidney transplant program. Eur Urol
25. Altinel M, Akinci S, Gunes ZE, et al. Open versus laparoscopic donor nephrectomy: perioperative parameters and graft functions. Transplant Proc
26. Andonian S, Herati AS, Atalla MA, et al. Laparoendoscopic single-site pfannenstiel donor nephrectomy. Urology
27. Aull MJ, Afaneh C, Charlton M, et al. A randomized, prospective, parallel group study of laparoscopic versus laparoendoscopic single site donor nephrectomy for kidney donation. Am J Transplant
28. Bachmann A, Wyler S, Wolff T, et al. Complications of retroperitoneoscopic living donor nephrectomy: single center experience after 164 cases. World J Urol
29. Baldan N, et al. Laparoscopic live donor nephrectomy: single center experience. Transplantation
30. Bargman V, Sundaram CP, Bernie J, et al. Randomized trial of laparoscopic donor nephrectomy with and without hand assistance. J Endourol
31. Barth RN, Phelan MW, Goldschen L, et al. Single-port donor nephrectomy provides improved patient satisfaction and equivalent outcomes. Ann Surg
32. Berends FJ, den Hoed PT, Bonjer HJ, et al. Technical considerations and pitfalls in laparoscopic live donornephrectomy. Surg Endosc
33. Bergman S, Feldman LS, Anidjar M, et al. "First, do no harm": monitoring outcomes during the transition from open to laparoscopic live donor nephrectomy in a Canadian centre. Can J Surg
34. Berney T, Malaise J, Mourad M, et al. Laparoscopic and open live donor nephrectomy: a cost/benefit study. Transpl Int
35. Bhattu A, et al. Robotic donor nephrectomy. J Endourol
36. Biancofiore G, Amorose G, Lugli D, et al. Perioperative management for laparoscopic kidney donation. Minerva Anestesiol
. 2003;69:681–686, 686–9.
37. Boorjian S, Munver R, Sosa RE, et al. Right laparoscopic live donor nephrectomy: a single institution experience. Transplantation
38. Branco AW, Kondo W, Branco Filho AJ, et al. A comparison of hand-assisted and pure laparoscopic techniques in live donor nephrectomy. Clinics (Sao Paulo)
39. Breda A, Veale J, Liao J, et al. Complications of laparoscopic living donor nephrectomy and their management: the UCLA experience. Urology
40. Brockmann JG, Senninger N, Wolters HH. Living donor of the kidney-open-video. Langenbecks Arch Surg
41. Broers EM, et al. Decreasing operating times and complication rates after laparoscopic donor nephrectomy by different techniques in highly experienced surgical teams. Eur Urol Supp
42. Brown SL, Biehl TR, Rawlins MC, et al. Laparoscopic live donor nephrectomy: a comparison with the conventional open approach. J Urol
43. Buell JF, Abreu SC, Hanaway MJ, et al. Right donor nephrectomy: a comparison of hand-assisted transperitoneal and retroperitoneal laparoscopic approaches. Transplantation
44. Buell JF, Edye M, Johnson M, et al. Are concerns over right laparoscopic donor nephrectomy unwarranted? Ann Surg
45. Buell JF, Hanaway MJ, Potter SR, et al. Hand-assisted laparoscopic living-donor nephrectomy as an alternative to traditional laparoscopic living-donor nephrectomy. Am J Transplant
46. Buresley S, Samhan M, Al-Mousawi M. Kuwait experience in laparoscopic donor nephrectomy: first 80 cases. Transplant Proc
47. Canes D, Berger A, Aron M, et al. Laparo-endoscopic single site (LESS) versus standard laparoscopic left donor nephrectomy: matched-pair comparison. Eur Urol
48. Cannon RM, Eng M, Marvin MR, et al. Laparoscopic living kidney donation at a single center: an examination of donor outcomes with increasing experience. Am Surg
49. Capocasale E, Iaria M, Vistoli F, et al. Incidence, diagnosis, and treatment of chylous leakage after laparoscopic live donor nephrectomy. Transplantation
50. Castillon-Vela I, et al. Prospective non randomized study comparing open donor nephrectomy (ODN), minimally invasive open donor nephrectomy (MIDN) and laparoscopic donor nephrectomy (LDN). Transplantation
51. Chandak P, Kessaris N, Challacombe B, et al. How safe is hand-assisted laparoscopic donor nephrectomy?—results of 200 live donor nephrectomies by two different techniques. Nephrol Dial Transplant
52. Chin EH, Hazzan D, Edye M, et al. The first decade of a laparoscopic donor nephrectomy program: effect of surgeon and institution experience with 512 cases from 1996 to 2006. J Am Coll Surg
53. Cho HJ, Lee JY, Kim JC, et al. How safe and effective is routine left hand-assisted laparoscopic donor nephrectomy with multiple renal arteries? A high-volume, single-center experience. Transplant Proc
54. Choi SW, Kim KS, Kim S, et al. Hand-assisted and pure laparoscopic living donor nephrectomy: a matched-cohort comparison over 10 yr at a single institute. Clin Transplant
55. Chueh SJ, Sankari B, Jones JS. Safety and technical considerationsof laparoendoscopic single site (LESS) live donor nephrectomy in a small-volumetransplant center. J Endourol
56. Chung MS, Kim SJ, Cho HJ, et al. Hand-assisted laparoscopic right donor nephrectomy: safety and feasibility. Korean J Urol
57. Cohen AJ, et al. Lessons learned from the introduction of a robotic assisted donor nephrectomy program. Am J Transplant
58. Crane C, Lam VW, Alsakran A, et al. Are there anatomical barriers to laparoscopic donor nephrectomy? ANZ J Surg
59. Dalla Valle R, Mazzoni MP, Capocasale E, et al. Laparoscopic donor nephrectomy: short learning curve. Transplant Proc
60. Desai MR, Ganpule AP, Gupta R, et al. Outcome of renal transplantation with multiple versus single renal arteries after laparoscopic live donor nephrectomy: a comparative study. Urology
61. Diner EK, Radolinski B, Murdock JD, et al. Right laparoscopic donor nephrectomy: the Washington Hospital Center experience. Urology
62. Disick GI, Shapiro ME, Miles RA, et al. Critical analysis of laparoscopic donor nephrectomy in the setting of complex renal vasculature: initial experience and intermediate outcomes. J Endourol
63. Dolce CJ, Keller JE, Walters KC, et al. Laparoscopic versus open live donor nephrectomy: outcomes analysis of 266 consecutive patients. Surg Endosc
64. Dols LF, Kok NF, d'Ancona FC, et al. Randomized controlled trial comparing hand-assisted retroperitoneoscopic versus standard laparoscopic donor nephrectomy. Transplantation
65. Dols LF, Kok NF, Terkivatan T, et al. Optimizing left-sided live kidney donation: hand-assisted retroperitoneoscopic as alternative to standard laparoscopic donor nephrectomy. Transpl Int
66. Dong J, Lu J, Zu Q, et al. Retroperitoneal laparoscopic live-donor nephrectomy: introduction of simple hand-assisted technique (without hand port). Transplant Proc
67. Duchene DA, Johnson DB, Li S, et al. Laparoscopic donor nephrectomy at a low volume living donor transplant center: successful outcomes can be expected. J Urol
68. Duchene DA, et al. Successful outcomes of older donors in laparoscopic donor nephrectomy. J Endourol
69. El-Galley R, Hood N, Young CJ, et al. Donor nephrectomy: a comparison of techniques and results of open, hand assisted and full laparoscopic nephrectomy. J Urol
70. Fisher C, Montgomery JS, Johnston WK 3rd, et al. 200 consecutive hand assisted laparoscopic donor nephrectomies: evolution of operative technique and outcomes. J Urol
71. Flowers JL, Jacobs S, Cho E, et al. Comparison of open and laparoscopic live donor nephrectomy. Ann Surg
. 1997;226:483–489; discussion 489–90.
72. Friedersdorff F, Werthemann P, Cash H, et al. Outcomes after laparoscopic living donor nephrectomy: comparison of two laparoscopic surgeons with different levels of expertise. BJU Int
73. Fronek J, et al. Hand assisted retroperitoneoscopic live donor nephrectomy with no side/anatomy exclusions: single centre experience with 139 cases. Transplantation
74. Geffner S, et al. Robotic-assisted laparoscopic donor nephrectomies: early experience and review of the literature. J Robotic Surg
75. Gimenez E, et al. Laparoendoscopic single site live donor nephrectomy: initial experience. J Urol
76. Gorodner V, Horgan S, Galvani C, et al. Routine left robotic-assisted laparoscopic donor nephrectomy is safe and effective regardless of the presence of vascular anomalies. Transpl Int
77. Gures N, et al. Comparison of the right and left laparoscopic live donor nephrectomies: a clinical case load. Eur Rev Med Pharmacol Sci
78. Hagen SM, et al. Robot-assisted live kidney donation: the Rotterdam experience. Transplant Int
79. Hakim N, Aboutaleb E, Syed A, et al. A fast and safe living donor “finger-assisted” nephrectomy technique: results of 359 cases. Transplant Proc
80. Harper JD, Breda A, Leppert JT, et al. Experience with 750 consecutive laparoscopic donor nephrectomies—is it time to use a standardized classification of complications? J Urol
81. He B, et al. Laparoscopic donor nephrectomy. J Minim Access Surg
82. Heimbach JK, Taler SJ, Prieto M. Obesity in living kidney donors: clinical characteristics and outcomes in the era of laparoscopic donor nephrectomy. Am J Transplant
83. Hensman C, Lionel G, Hewett P. Laparoscopic live donor nephrectomy: the preliminary experience. Aust N Z J Surg
84. Hoda MR, et al. Prospective, nonrandomized comparison between right- and left-sided hand-assisted laparoscopic donor nephrectomy. Transplant Proc
85. Hofker HS, Nijboer WN, Niesing J, et al. A randomized clinical trial of living donor nephrectomy: a plea for a differentiated appraisal of mini-open muscle splitting incision and hand-assisted laparoscopic donor nephrectomy. Transpl Int
86. Horgan S. Minimally invasive donor nephrectomy using a supra-pubic approach: Initial clinical experience. Surg Endosc Interv Tech
87. Hsu TH, Su LM, Ratner LE, et al. Renovascular complications of laparoscopic donor nephrectomy. Urology
88. Hu JC, Lui CH, Treat EG, et al. Determinants of laparoscopic donor nephrectomy outcomes. Eur Urol
89. Hubert J, et al. Robotic-assisted laparoscopic living donor nephrectomies: experience in 100 cases. Int J Med Rob Comput Assisted Surg
90. Hung CJ, Lin YJ, Chang SS, et al. Kidney grafts with multiple renal arteries is no longer a relative contraindication with advance in surgical techniques of laparoscopic donor nephrectomy. Transplant Proc
91. Jacobs SC, et al. Laparoscopic donor nephrectomy: the University of Maryland 6-year experience. J Urol
92. Johnson MW, et al. Technique of right laparoscopic donor nephrectomy: a single center experience. Am J Transplant
93. Kapoor A, et al. Outcomes of laparoscopic donor nephrectomy in the presence of multiple renal arteries. Urol Ann
94. Kercher K, et al. Hand-assisted laparoscopic donor nephrectomy minimizes warm ischemia. Urology
95. Kessaris N, Heap S. Adopting the retroperitoneal approach to live donor nephrectomy—confessions of a converted surgeon! Transplant Int
96. Khan I, et al. Hand assisted laparoscopic donor nephrectomy, outcomes and complications-a single center study in a developing country. Transplantation
97. Khauli RB, El-Hout Y, Hussein M, et al. A controlled sequential evaluation of open donor nephrectomy versus classical and modified laparoscopic donor nephrectomy: an update. Transplant Proc
98. Kim BS, Yoo ES, Kim TH, et al. Chylous ascites as a complication of laparoscopic nephrectomy. J Urol
99. Klop KWJ, Kok NF, Dols LF, et al. Can right-sided hand-assisted retroperitoneoscopic donor nephrectomy be advocated above standard laparoscopic donor nephrectomy: a randomized pilot study. Transpl Int
100. Kohei N, Kazuya O, Hirai T, et al. Retroperitoneoscopic living donor nephrectomy: experience of 425 cases at a single center. J Endourol
101. Kok NF, Alwayn IP, Schouten O, et al. Mini-incision open donor nephrectomy as an alternative to classic lumbotomy: evolution of the open approach. Transpl Int
102. Kok NF, van der Wal JB, Alwayn IP, et al. Laparoscopic kidney donation: the impact of adhesions. Surg Endosc
103. Koning JL, Nicolay LI, Jellison F, et al. Ocular complications after open and hand-assisted laparoscopic donor nephrectomy. Urology
104. Ku JH, Yeo WG, Han DH, et al. Hand-assisted laparoscopic and open living donor nephrectomy in Korea. Int J Urol
105. Kumar A, et al. Analysis of 1000 cases of laparoscopic donor nephrectomy from a developing country. Transplantation
106. Kuo C, Johnson LB, Sitzmann JV. Laparoscopic donor nephrectomy with a 23-hour stay: a new standard for transplantation surgery. Ann Surg
107. Kurien A, Rajapurkar S, Sinha L, et al. First prize: standard laparoscopic donor nephrectomy versus laparoendoscopic single-site donor nephrectomy: a randomized comparative study. J Endourol
108. Lai IR, Yang CY, Yeh CC, et al. Hand-assisted versus total laparoscopic live donor nephrectomy: comparison and technique evolution at a single center in Taiwan. Clin Transplant
109. Lallas CD, Castle EP, Schlinkert RT, et al. The development of a laparoscopic donor nephrectomy program in a de novo renal transplant program: Evolution of technique and results in over 200 cases. JSLS
110. LaMattina J, et al. Five year experience with single-port donor nephrectomy as a standardized approach. Transplantation
111. Lee YS, Jeon HG, Lee SR, et al. The feasibility of solo-surgeon living donor nephrectomy: initial experience using video-assisted minilaparotomy surgery. Surg Endosc
112. Lenaghan D, et al. Laparoscopic live donor nephrectomy: a review of 50 consecutive cases. BJU Int
113. Leventhal J.R., et al. Laparoscopic live donor nephrectomy—is it safe?: analysis of 80 consecutive cases and comparison with open nephrectomy. …, 2000.
114. Leventhal JR, Paunescu S, Baker TB, et al. A decade of minimally invasive donation: experience with more than 1200 laparoscopic donor nephrectomies at a single institution. Clin Transplant
115. Lewis GR, Brook NR, Waller JR, et al. A comparison of traditional open, minimal-incision donor nephrectomy and laparoscopic donor nephrectomy. Transpl Int
116. Lind MY, Hazebroek EJ, Hop WC, et al. Right-sided laparoscopic live-donor nephrectomy: is reluctance still justified? Transplantation
117. Lucas SM, Liaw A, Mhapsekar R, et al. Comparison of donor, and early and late recipient outcomes following hand assisted and laparoscopic donor nephrectomy. J Urol
118. Ma L, Ye J, Huang Y, et al. Retroperitoneoscopic live-donor nephrectomy: 5-year single-center experience in China. Int J Urol
119. Maartense S, Idu M, Bemelman FJ, et al. Hand-assisted laparoscopic live donor nephrectomy. Br J Surg
120. Maione G, Sansalone CV, Aseni P, et al. Laparosopic hand-assisted living donor nephrectomy: The niguarda experience. Transplant Proc
121. Melcher ML, Carter JT, Posselt A, et al. More than 500 consecutive laparoscopic donor nephrectomies without conversion or repeated surgery. Arch Surg
122. Milner JE, et al. Outcomes of 250 consecutive laparoscopic living donor nephrectomies using the Dindo-Clavien complication classification system. Am J Transplant
123. Minnee RC, Bemelman F, Kox C, et al. Comparison of hand-assisted laparoscopic and open donor nephrectomy in living donors. Int J Urol
124. Minz M, et al. Comparison of transumbilical and conventional (pfannenstiel) laparoscopic donor nephrectomy. Transplantation
125. Mitre AI, Dénes FT, Piovesan AC, et al. Laparoscopic nephrectomy in live donor. Int Braz J Urol
126. Mjøen G, Holdaas H, Pfeffer P, et al. Minimally invasive living donor nephrectomy—introduction of hand-assistance. Transpl Int
127. Rao MM, Russell CH. Laparoscopic live donor nephrectomy. ANZ J Surg
128. Morrissey E, Gautam A, Amaral JF, et al. Keeping up with the Jones's: open donor nephrectomy in the laparoscopic era. Transplant Proc
129. Muthu C, McCall J, Windsor J, et al. The Auckland experience with laparoscopic donor nephrectomy. N Z Med J
130. Narita S, et al. Outcome of right hand-assisted retroperitoneoscopic living donor nephrectomy. Urology
. 2006;67:496–500; discussion 500–1.
131. Neipp M, Jackobs S, Becker T, et al. Living donor nephrectomy: flank incision versus anterior vertical mini-incision. Transplantation
132. Ng CS, Abreu SC, Abou El-Fettouh HI, et al. Right retroperitoneal versus left transperitoneal laparoscopic live donor nephrectomy. Urology
133. Nicholson ML, Kaushik M, Lewis GR, et al. Randomized clinical trial of laparoscopic versus open donor nephrectomy. Br J Surg
134. O'Brien B, Mastoridis S, Crane J, et al. Safety of nephrectomy in morbidly obese donors. Exp Clin Transplant
135. Odland MD, Ney AL, Jacobs DM, et al. Initial experience with laparoscopic live donor nephrectomy. Surgery
136. Øyen O, Andersen M, Mathisen L, et al. Laparoscopic versus open living-donor nephrectomy: experiences from a prospective, randomized, single-center study focusing on donor safety. Transplantation
137. Pandarinath SR, Choudhary B, Chouhan HS, et al. Transperitoneal laparoscopic left versus right live donor nephrectomy: comparison of outcomes. Indian J Urol
138. Paul A, Treckmann J, Gallinat A, et al. Current concepts in transplant surgery: laparoscopic living donor of the kidney. Langenbecks Arch Surg
139. Percegona LS, Bignelli AT, Adamy A, et al. Hand-assisted laparoscopic donor nephrectomy: comparison to pure laparoscopic donor nephrectomy. Transplant Proc
140. Peters TG, Repper SM, Vincent MC, et al. One hundred consecutive living kidney donors: modern issues and outcomes. Clin Transplant
141. Posselt AM, Mahanty H, Kang SM, et al. Laparoscopic right donor nephrectomy: a large single-center experience. Transplantation
142. Potter SR. Single-surgeon laparoscopic donor nephrectomy and renal transplantation. Urology
143. Power RE, Preston JM, Griffin A, et al. Laparoscopic vs open living donor nephrectomy: a contemporary series from one centre. BJU Int
144. Ramasamy R, Afaneh C, Katz M, et al. Comparison of complications of laparoscopic versus laparoendoscopic single site donor nephrectomy using the modified Clavien grading system. J Urol
145. Ratner LE, Montgomery RA, Kavoussi LR. Laparoscopic live donor nephrectomy: the four year Johns Hopkins University experience. Nephrol Dial Transplant
146. Rawlins MC, Hefty TL, Brown SL, et al. Learning laparoscopic donor nephrectomy safely: a report on 100 cases. Arch Surg
. 2002;137:531–534; discussion 534–5.
147. Renoult E, Hubert J, Ladrière M, et al. Robot-assisted laparoscopic and open live-donor nephrectomy: a comparison of donor morbidity and early renal allograft outcomes. Nephrol Dial Transplant
148. Richards G, et al. Hand-assisted laparoscopic donor nephrectomy using only 5 mm ports. J Endourol
149. Richstone L, Rais-Bahrami S, Waingankar N, et al. Pfannenstiel laparoendoscopic single-site (LESS) vs conventional multiport laparoscopic live donor nephrectomy: a prospective randomized controlled trial. BJU Int
150. Rocca X, Espinoza O, Hidalgo F, et al. Laparoscopic nephrectomy: safe and comfortable surgical alternative for living donors and for good results of graft function. Transplant Proc
151. Ruiz-Deya G, Cheng S, Palmer E, et al. Open donor, laparoscopic donor and hand assisted laparoscopic donor nephrectomy: a comparison of outcomes. J Urol
. 2001;166:1270–1273; discussion 1273–1274.
152. Ruszat R, Sulser T, Dickenmann M, et al. Retroperitoneoscopic donor nephrectomy: donor outcome and complication rate in comparison with three different techniques. World J Urol
153. Saad S, Paul A, Treckmann J, et al. Laparoscopic live donor nephrectomy for right kidneys: experience in a German community hospital. Surg Endosc
154. Sadek MA, et al. Right laparoscopic live-donor nephrectomy. J Endourol
155. Samarasekera D, Kim DS, Wang R, et al. Laparoscopy, dorsal lumbotomy and flank incision live donor nephrectomy: comparison of donor outcomes. Can Urol Assoc J
156. Sawatzky M, Altaf A, Ellsmere J, et al. Is right laparoscopic donor nephrectomy right? Surg Endosc
157. Schnitzbauer AA, Loss M, Hornung M, et al. Mini-incision for strictly retroperitoneal nephrectomy in living kidney donation vs flank incision. Nephrol Dial Transplant
158. Seong IS, Kim JC, Hwangbo K, et al. Comparison of hand-assisted laparoscopic and open donor nephrectomy: a single-center experience from South Korea. J Endourol
159. Shirodkar S, Sageshima J, Bird VG, et al. Living donor nephrectomy: University of miami technique and current results. Arch Esp Urol
160. Simforoosh N, Basiri A, Tabibi A, et al. Comparison of laparoscopic and open donor nephrectomy: a randomized controlled trial. BJU Int
161. Sinh T, et al. Retroperitoneal laparoscopic living donor nephrectomy: a simple technique in Cho Ray Hospital. Urology
162. Siqueira TM Jr, Kuo RL, Gardner TA, et al. Major complications in 213 laparoscopic nephrectomy cases: the Indianapolis experience. J Urol
163. Srivastava A, Gupta N, Kumar A. Evolution of the technique of laparoscopic live donor nephrectomy at a single center: experience with more than 350 cases. Urol Int
164. Srivastava A, Tripathi DM, Zaman W, et al. Subcostal versus transcostal mini donor nephrectomy: is rib resection responsible for pain related donor morbidity. J Urol
165. Stifelman MD, Hull D, Sosa RE, et al. Hand assisted laparoscopic donor nephrectomy: a comparison with the open approach. J Urol
166. Su LM, Ratner LE, Montgomery RA, et al. Laparoscopic live donor nephrectomy: trends in donor and recipient morbidity following 381 consecutive cases. Ann Surg
167. Sudhindran S, Sanjeevan KV, Saheed CS, et al. Initial experience with laparoscopic donor nephrectomies. Transplant Proc
168. Sulser T, Gürke L, Langer I, et al. Retroperitoneoscopic living-donor nephrectomy: first clinical experiences in 19 operations. J Endourol
169. Sundaram C, Martin GL, Guise A, et al. Complications after a 5-year experience with laparoscopic donor nephrectomy: the Indiana University experience. Surg Endosc
170. Taber DJ, Ashcraft E, Cattanach LA, et al. No difference between smokers, former smokers, or nonsmokers in the operative outcomes of laparoscopic donor nephrectomies. Surg Laparosc Endosc Percutan Tech
171. Tanabe K, Miyamoto N, Tokumoto T, et al. Retroperitoneoscopic live donor nephrectomy: extended experience in a single center. Transplant Proc
172. Taweemonkongsap T, Nualyong C, Amornvesukit T, et al. Laparoscopic live-donor nephrectomy: a comparison with the open technique and how to reach quality standards: a single-center experience in Thailand. Transplant Proc
173. Troppmann C, Wiesmann K, McVicar JP, et al. Increased transplantation of kidneys with multiple renal arteries in the laparoscopic live donor nephrectomy era: surgical technique and surgical and nonsurgical donor and recipient outcomes. Arch Surg
174. Tsoulfas G, Agorastou P, Ko D, et al. Laparoscopic living donor nephrectomy: is there a difference between using a left or a right kidney? Transplant Proc
175. Tsuchiya N, Iinuma M, Habuchi T, et al. Hand-assisted retroperitoneoscopic nephrectomy for living kidney transplantation: initial 44 cases. Urology
176. Ueda E, et al. Clinical characteristics and outcomes of donor nephrecomy for obese living kidney donor's. Transplantation
177. Ungbhakorn P, Kongchareonsombat W, Leenanupan C, et al. Comparative outcomes of open nephrectomy, hand-assisted laparoscopic nephrectomy, and full laparoscopic nephrectomy for living donors. Transplant Proc
178. Van der Merwe A, Heyns CF. Retroperitoneoscopic live donor nephrectomy: review of the first 50 cases at Tygerberg Hospital, Cape Town, South Africa. S Afr J Surg
179. Velidedeoglu E, Williams N, Brayman KL, et al. Comparison of open, laparoscopic, and hand-assisted approaches to live-donor nephrectomy. Transplantation
180. Villeda-Sandoval CI, Rodríguez-Covarrubias F, Cortés-Aguilar G, et al. Hand-assisted laparoscopic versus open donor nephrectomy: a retrospective comparison of perioperative and functional results in a tertiary care center in Mexico. Transplant Proc
181. Wadström J, Biglarnia A, Gjertsen H, et al. Introducing hand-assisted retroperitoneoscopic live donor nephrectomy: learning curves and development based on 413 consecutive cases in four centers. Transplantation
182. Waller JR, Hiley AL, Mullin EJ, et al. Living kidney donation: a comparison of laparoscopic and conventional open operations. Postgrad Med J
183. Wang GJ, Afaneh C, Aull M, et al. Laparoendoscopic single site live donor nephrectomy: single institution report of initial 100 cases. J Urol
184. Waxman SW, Winfield HN. Complications of laparoscopic renal surgery. J Endourol
185. Wilson CH, Bhatti AA, Rix DA, et al. Comparison of laparoscopic and open donor nephrectomy: UK experience. BJU Int
186. Wolf JS Jr, Marcovich R, Merion RM, et al. Prospective, case matched comparison of hand assisted laparoscopic and open surgical live donor nephrectomy. J Urol
187. Wolf JS Jr, Merion RM, Leichtman AB, et al. Randomized controlled trial of hand-assisted laparoscopic versus open surgical live donor nephrectomy. Transplantation
188. Yang SL, Harkaway R, Badosa F, et al. Minimal incision living donor nephrectomy: improvement in patient outcome. Urology
189. Yoshimura K, Takahara S, Kyakuno M, et al. Retroperitoneoscopic living related-donor nephrectomy: clinical outcomes of 50 consecutive cases and comparison with open donor nephrectomy. J Endourol
190. Alessimi A, Adam E, Haber GP, et al. LESS living donor nephrectomy: surgical technique and results. Urol Ann
191. Amit B, et al. Robotic assisted laparoscopic living donor nephrectomy. Indian J Urol
192. Biglarnia AR. Retroperitoneoscopic hand-assisted live donor nephrectomy—a single center experience. Ann Saudi Med
193. Cavdaroglu O, Gurluler E, Cakir U, et al. Laparascopic donor nephrectomy is safe for extremely old donors and provides a good outcome for their recipients. Transplant Proc
194. Cho HJ, Choi SW, Kim KS, et al. Laparoendoscopic single-site plus one-port donor nephrectomy: analysis of 169 cases. J Laparoendosc Adv Surg Tech A
195. Kanashiro H, Lopes RI, Saito FA, et al. Comparison between laparoscopic and subcostal mini-incision for live donor nephrectomy. Einstein (Sao Paulo)
196. Kashiwadate T, Tokodai K, Amada N, et al. Right versus left retroperitoneoscopic living-donor nephrectomy. Int Urol Nephrol
197. Kim BS, Kim KH, Yoo ES, et al. Hybrid technique using a Satinsky clamp for right-sided transperitoneal hand-assisted laparoscopic donor nephrectomy: comparison with left-sided standard hand-assisted laparoscopic technique. Urology
198. Kroencke S, Schulz KH, Nashan B, et al. Anterior vertical mini-incision vs. retroperitoneoscopic nephrectomy in living kidney donation: a prospective study on donors' quality of life and clinical outcome. Clin Transplant
199. Kumar A, et al. Complications following transperitoneal hand-assisted laparoscopic donor nephrectomy-experience of first 141 cases. Transpl Int
200. Paraskeva P, et al. Readmission within 30 days post hand assisted laparoscopic donor nephrectomy. Transpl Int
201. Peri L, Musquera M, Vilaseca A, et al. Perioperative outcome and female sexual function after laparoscopic transvaginal NOTES-assisted nephrectomy. World J Urol
202. Rajab A, Pelletier R. The safety of hand-assisted laparoscopic living donor nephrectomy: The Ohio State University experience with 1500 cases. Clin Transplant
203. Rogers A, et al. Donor safety can be maintained when training surgeons in laparoscopic donor nephrectomy in a sequential manner, within a team environment. Transpl Int
204. Song G, Jeong IG, Kim YH, et al. Kidney laterality and the safety of hand-assisted live donor nephrectomy: review of 1000 consecutive cases at a single center. Urology
205. Stamatakis L, Mercado MA, Choi JM. Comparison of laparoendoscopic single site (LESS) and conventional laparoscopic donor nephrectomy at a single institution. BJU Int
206. Sureka SK, Srivastava A, Agarwal S, et al. Prevention of orchialgia after left-sided laparoscopic donor nephrectomy—a prospective study. J Endourol
207. Treat EG, Schulam PG, Gritsch HA, et al. Evolution of laparoscopic donor nephrectomy technique and outcomes: a single-center experience with more than 1300 cases. Urology
208. You D, Lee C, Jeong IG, et al. Transition from hand-assisted to pure laparoscopic donor nephrectomy. JSLS
209. Bhattu AS, Ganpule A, Sabnis RB, et al. Robot-assisted laparoscopic donor nephrectomy vs standard laparoscopic donor nephrectomy: a prospective randomized comparative study. J Endourol
210. Kok NFM, Lind MY, Hansson BM, et al. Comparison of laparoscopic and mini incision open donor nephrectomy: single blind, randomised controlled clinical trial. BMJ
211. Legemaate J Informed Consent. http://www.nvpc.nl/uploads/stand/63Richtlijn%20Informed%20Consent.pdf
. Published 2001. Accessed May 11th, 2016.
212. Janki S, Verver D, Klop KW, et al. Vascular management during live donor nephrectomy: an online survey among transplant surgeons. Am J Transplant
213. Friedman AL, Peters TG, Ratner LE. Regulatory failure contributing to deaths of live kidney donors. Am J Transplant