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Letters to the Editor

TOPICAL FK506 OINTMENT FOR SKIN GRAFTING

Yuzawa, Kenji1; Fukao, Katashi

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We were amazed to read an article by Fujita et al. (1) in the September 27, 1997, issue stating that topical administration of FK506 ointment on a skin graft was effective in the suppression of skin allograft rejection in the rat. The novel idea of using FK506 ointment topically for skin grafting was first formed by us and was reported by us to be effective for skin grafting in our original article (2). We daresay that the difference between the two articles was the difference of the animals used in skin grafting. We used mice and Fujita et al. (1) used rats. The ideas and the conclusions were completely the same. Our article was published in June 1996 and the article in Transplantation was received in March 1997. We regret that the authors of the article inTransplantation should be so cursory in their review of the literature. Even if the skin grafting, particularly in the rat, was meaningful, nothing should excuse neglecting our article in the references.

Kenji Yuzawa1

Katashi Fukao

Department of Surgery; Institute of Clinical Medicine; University of Tsukuba; Tsukuba, Ibaraki-ken, Japan

REFERENCES

1. Fujita T, Takahashi S, Yagihashi A, et al. Prolonged survival of rat skin allograft by treatment with FK506 ointment. Transplantation 1997; 64: 922.
2. Yuzawa K, Taniguchi H, Seino K, et al. Topical immunosuppression in skin grafting with FK506 ointment. Transplant Proc 1996; 28: 1387.
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