One method for increasing the donor pool for orthotopic liver transplantations (OLTs) is to use uncontrolled donations after circulatory death (uDCDs).
From January 2006 to December 2016, we performed 75 OLTs using uDCD livers. The control group comprised a sample of 265 OLTs using livers of donations after brain death (DBDs). A comparative study was performed.
Of 256 potential uDCD donors cannulated, 75 (29.3%) livers were accepted for OLT. The amount of hemoderivatives transfused was significantly higher in the uDCD group. The rate of primary nonfunction was also significantly higher (p = 0.031) in uDCD recipients (8%) than in DBD recipients (1.5%). The overall rate of biliary complications was significantly higher (p = 0.001) in uDCD recipients (23 cases, 30.6%) than DBD recipients (28 cases, 10.6%). In the uDCD group, 1-, 3-, and 5-year patient survival rates were 82.7%, 73%, and 71.5%, respectively; in the DBD group, they were 89%, 83.7%, and 78.8%, respectively (p = 0.180). In the uDCD group, 1-, 3- and 5-year graft survival rates were 73.3%, 65.1%, and 63.6%, respectively; in the DBD group, they were 87.1%, 81.9%, and 76.5%, respectively (p = 0.013). Multivariate analysis showed that independent risk factors for patient and graft survival were intraoperative transfusion of more than six units of packed red blood cell concentrates and recipients who were older than 60 years.
Although graft survival is significantly lower using uDCD livers, 5-year patient survival in recipients of DBD and uDCD livers is similar. After careful selection, the livers of uDCD can be selectively used for OLT.
1Unit of Hepato-Pancreato-Biliary Surgery and Abdominal Organ Transplantation, Department of Surgery, Doce de Octubre Hospital. Instituto de Investigación. Faculty of Medicine, Department of Surgery, Complutense University, Madrid, Spain.
2Unit of Infectious Diseases, Doce de Octubre Hospital, Complutense University, Madrid, Spain.
Disclosure: The authors declare no conflicts of interest.
The authors declare no applicable funding.
3Presented this research as oral communication at the 27th International Congress of The Transplantation Society (2018) held in Madrid, Spain.
*Corresponding Author: Carlos Jiménez-Romero PhD, FACS. Prof. of Surgery. Unit of HPB Surgery and Abdominal Organ Transplantation, Doce de Octubre University Hospital, 4ª Planta, Ctra. Andalucía Km 5.4, 28041, Madrid, Spain. Phone: +34 91 3908294. Fax: +34 91 519271. E-mail: firstname.lastname@example.org