World Health Assembly Resolution WHA 63.22 mandated WHO to facilitate Member State access to appropriate information on Medical Products of Human Origin (MPHO), including collecting data on serious adverse events and reactions. To meet this challenge, the Italian National Transplant Center, with a mandate from WHO, has built and maintains an open access searchable database of instructive records on disease transmission and other MPHO adverse occurrences.
BUILDING AND UPDATING THE LIBRARY:
One record in the Notify Library describes a specific type of adverse occurrence in 1 type of MPHO and might be linked with 1 or multiple different references. The record inclusion criteria are that it has been reliably documented in a published article or official vigilance reporting system and that it has instructive value for the fields of transfusion, transplantation or assisted reproduction. The selection and review of references for publication is carried out by international experts who collaborate in 5 topic-specific editorial groups: infection and malignancy transmission, living donor reactions, process related incidents and clinical complications. New relevant references are identified through systematic searches and proactive communication by the experts.
The Library contains 1733 records, quoting 2632 references. Of the records, 41.8% are related to organs, 20.8% to blood and blood components, 16.5% to hematopoietic progenitor cells, 15.2% to tissues, 4.2% to reproductive tissues and cells and 1.5% to other MPHO.
Notify Library is the first open access, searchable database of systematically identified reports of disease transmission and other adverse occurrences arising from the donation and clinical application of MPHO.