1 Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clínic, Institut D’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain.
2 CIBEREHD (Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas).
3 Health Care Provider of the European Reference Network on Rare Liver Disorders (ERN-Liver).
4 Service d’Hépatologie, Centre de Référence des Maladies Vasculaires du Foie, DHU Unity, Pôle des Maladies de l’Appareil Digestif, Hôpital Beaujon, AP-HP, Clichy, France.
5 Regional Institute of Gastroenterology and Hepatology “Octavian Fodor,” Hepatology Department and “Iuliu Hatieganu” University of Medicine and Pharmacy, 3rd Medical Clinic, Cluj-Napoca, Romania.
6 The Liver Unit, University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom.
7 Department of Gastroenterology and Hepatology, University Hospital KU Leuven, Leuven, Belgium.
8 Liver Transplantation Unit, Hospital Clínic, Institut de Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.
9 CIBERehd, Instituto de Salud Carlos III, Madrid, Spain.
10 Department of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, IRYCIS, CIBERehd, Universidad de Alcalá, Madrid, Spain.
11 Service d’Hépato-Gastroentérologie, Hôpitaux Universitaires de Genève, Geneva, Switzerland. Service d’Hépato-Gastroentérologie, CHU de Tours, France.
12 Université de Paris, Centre de recherche sur l’inflammation, Inserm, U1149, CNRS, ERL8252, Paris, France.
13 Department of Surgery, Division of Hepatobiliary and General Surgery, Institut de Malalties Digestives I Metabòliques (IMDiM), Hospital Clínic, University of Barcelona, Barcelona, Spain.
14 Liver Unit, Centro Hospitalar do Porto, Hospital Sto Antonio, Porto, Portugal.
15 Department of Gastroenterology, Lokmanya Tilak Municipal General Hospital and Lokmanya Tilak Municipal Medical College, Sion, Mumbai, India.
16 Department of Hepatology, Rangueil Hospital, CHU Toulouse, University Paul Sabatier of Toulouse, Toulouse, France.
17 Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium.
18 Liver Transplantation and Hepatology Unit, Hospital Universitari i Politécnic La Fe, Valencia, Spain.
19 CIBERehd (Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas, Valencia Spain), Instituto de Salud Carlos III.
20 Liver Unit, Hospital U, Puerta de Hierro, Universidad Autònoma de Madrid, CIBERehd, Madrid, Spain.
21 Department of Gastroenterology and Hepatology, University of Modena & Reggio Emilia and Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.
22 Department of Gastroenterology and Hepatology, Centre for the Diagnosis and Treatment of Portal Hypertension, “Sapienza” University of Rome, Rome, Italy.
23 Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Division of Gastroenterology and Hepatology, CRC “A.M.and A.Miglaivacca” Center for Liver Disease, Milan, Italy.
24 Hepatology Group, Swiss Liver Center, University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern, Bern, Switzerland.
25 Liver Unit, Department of Gastroenterology Hospital Sant Pau, Barcelona, Autonomous University, Barcelona, Spain.
26 Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain.
27 Department of Gastroenterology and Hepatology, University Gregorio Marañón Hospital, liSGM, CIBERehd, Barcelona, Spain.
28 Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
29 Liver Unit, Digestive Disease Department, Marqués de Valdecilla University Hospital, Santander, Cantabria University, Cantabria, Spain.
30 Liver Unit, University Hospital Germans Trias i Pujol, Badalona, Spain.
31 Centre for Biomedical Research in Liver and Digestive Diseases Network (CIBERehd).
32 Liver Unit, Department of Gastroenterology and Hepatology, Hospital Universitario Central de Asturias, University of Oviedo, Oviedo, Spain.
33 Liver Unit, Department of Gastroenterology, Hospital Virgen de la Salud, Toledo, Spain.
34 Vienna Hepatic Hemodynamic Lab, Medical University of Vienna, Vienna, Austria.
35 Department of Gastroenterology and Hepatology, Hospital de Santa Maria - Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal.
36 Liver Unit, Department of Internal Medicine, Hospital Universitari Vall d’Hebrón, Vall d’Hebron Research Institute (VHIR), Vall d’Hebron Barcelona Hospital Campus, CIBERehd, Universitat Autònoma de Barcelona, Barcelona, Spain.
37 Liver Unit, Department of Gastroenterology and Hepatology, Hospital Universitario de Canarias, Tenerife, Spain.
38 Department of Histopathology, Hospital Clínic, Institut de Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.
39 Department of Radiology, Hospital Clínic, Institut de Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.
40 Servizio di Gastroenterología e Epatologia, Ente Ospedaliero Cantonale, Università della Svizzera Italiana, Lugano, Switzerland.
41 Liver ICU, Liver Unit, Hospital Clínic, University of Barcelona, Barcelona, Spain.
42 Institut d’Investigacions Biomèdiques August-Pi-Sunyer (IDIBAPS), Barcelona, Spain.
43 Anesthesiology Department, Hospital Clinic-IDIBAPS, Barcelona, Spain.
44 Translational Hepatology, Department of Internal Medicine I, Goethe University Frankfurt, Frankfurt, Germany.
45 European Foundation for Study of Chronic Liver Failure, Barcelona, Spain.
Received 24 August 2022. Revision received 20 October 2022.
Accepted 6 November 2022.
V.H.-G. received speaker fees from Gore. J.C.G.-P. advises for GORE, Cook, and Shionogi. The other authors declare no conflicts of interest.
This study has been funded by Instituto de Salud Carlos III (ISCIII) and by the Ministry of Education and Science through the project SAF PID2019-105/48RB-100 and PI18/00205 - PI21/00131 and co-funded by the European Union (Fondo Europeo de Desarrollo Regional FEDER y Fondo Social Europeo Plus FSE+) and AGAUR SGR2017-517 (Agència de Gestió d’Ajuts Universitaris i de Recerca) and CIBEREHD-EHDG26 G_P funded by the Instituto de Salud Carlos III. A.B. is the recipient of a Juan Rodés JR20/0024 grant and M.M. is the recipient of a Río Hortega CM19/00024 grant from Instituto de Salud Carlos III, Spain. M.P. is funded by the Ernst-und-Berta Grimmke Foundation (No. 5/19) and BONFOR research program of the University of Bonn (grant ID 2020-2A-07 and 2021-2A-07) and by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy – EXC2151 – 390873048. J.T. was supported by the German Research Foundation (DFG) project ID 403224013 – SFB 1382 (A09), by the German Federal Ministry of Education and Research (BMBF) for the DEEP-HCC project and by the Hessian Ministry of Higher Education, Research and the Arts (HMWK) for the ENABLE cluster project. The MICROB-PREDICT (project ID 825694), DECISION (project ID 847949), GALAXY (project ID 668031), LIVERHOPE (project ID 731875), and IHMCSA (project ID 964590) projects have received funding from the European Union’s Horizon 2020 research and innovation program. The article reflects only the authors’ views, and the European Commission is not responsible for any use that may be made of the information it contains. The funders had no influence on the study design, data collection and analysis, decision to publish, or preparation of the article.
M.M. and H.G.-L. share first authorship. F.D. and J.C.G.-P. share seniorship.
M.M., H.G., O.N., V.H.-G., P.-E.R., F.D., G.C., and J.C.G. designed the research, analyzed data, and wrote the article. M.M., H.G. O.N., L.O., A.G., F.D., S.H., L.T., F.I., L.T., S.G., H.L., L.S., K.R., G.T., N.B., Ch.B., E.A., C.R., R.D., M.P., AL.K.; X.V., H.D., G.S., P.O., E.L., F.N., A.B., J.I.F., H.M., A.A., Á.P., F.T., V.A., C.A.N., M.R., L.E., C.F., Y.F., B.S., G.S., M.M., A.S., F.D., M.S., C.G.-A., A.D., Á.G.C., A.d.G., E.R., A.B., J.G., O.R., C.F., C.N.F., T.R., M.R., R.M.M., J.L.C., J.C., J.T., R.B., X.V., B.P., C.V., A.B., M.P., V.L.M., F.N., Cr.B., A.A., F.S., and D.T. collected and reviewed the data and the article.
Supplemental digital content (SDC) is available for this article. Direct URL citations appear in the printed text, and links to the digital files are provided in the HTML text of this article on the journal’s Web site (www.transplantjournal.com).
Correspondence: Juan Carlos García-Pagán, MD, PhD, Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic, Villarroel 170, Barcelona 08036, Spain. ([email protected]).
