1 Department of Thoracic Surgery and Lung Transplantation, Foch Hospital, Suresnes, France.
2 INRAE, UVSQ, VIM, Université Paris-Saclay, Jouy-en-Josas, France.
3 INRAE, AgroParisTech, GABI, Université Paris-Saclay, Jouy-en-Josas, France.
4 UVSQ, INRAE, BREED, Université Paris-Saclay, Jouy-en-Josas, France.
5 Department of Pneumology, Foch Hospital, Suresnes, France.
6 Department of Anesthesiology, Foch Hospital, Suresnes, France.
7 Université de Paris, Paris, France.
Received 27 May 2021. Revision received 3 August 2021.
Accepted 4 August 2021.
The study was financed by Agence de la Biomédecine, by Fondation Foch (fondation-foch.com) and by VIM-INRAE internal support.
J.D.W. participated to the design of the study, performed the pig surgery and the ex vivo lung perfusion experiment, and participated in the writing of the article. M.G. participated in the design of the study. J.E. performed the lactate deshydrogenase measurements, performed the statistical analyses of the physiological data and of the perfusate data, and drew Figures 1 and 2. L.J. performed the bioinformatics and biostatistical analyses of the genomic data. J.-J.L. managed the animal experiment and wrote the ethic application. C.R. managed the surgery platform. F.B. performed the cytokine dosages. C.U. performed the RNA extractions and quality check. A.R. participated in the design of the study. M.L.G. participated in the design of the study. D.J. participated in the design of the study and provided his expertise in the dialysis procedure management. I.S.-C. participated in the design of the study, supervised the biological analyses, performed the functional genomics analyses, drew the functional genomic figures, and wrote the article. E.S. conceptualized, designed, and supervised the whole study, raised funding, supervised, and participated in the writing of the article. All named authors have agreed to its submission.
The authors declare no funding and conflicts of interest.
Supplemental digital content (SDC) is available for this article. Direct URL citations appear in the printed text, and links to the digital files are provided in the HTML text of this article on the journal’s Web site (www.transplantjournal.com).
Correspondence: Isabelle Schwartz-Cornil, PhD, Centre de Recherche INRAE, UMR 892 VIM “Virologie et Immunologie Moléculaires” Equipe Vaccins Immunopathologie Immunomodulation (V2I), Bâtiment 440, Etage 1, Bureau 703, 78352 Jouy-en-Josas Cedex, France. ([email protected]).
