Antibody-mediated rejection continues to hinder long-term survival of solid organ allografts. Natural antibodies (Nabs) with polyreactive and autoreactive properties have recently emerged as potential contributors to antibody-mediated graft rejection. This review discusses Nabs, their functions in health and disease, their significance in rejection following kidney, heart, and lung transplantation, and their implication in serum reactivity to key antigens associated with rejection. Finally, potential effector mechanisms of Nabs in the context of transplantation are explored.
1 Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY.
Received 18 January 2019. Revision received 15 March 2019.
Accepted 21 March 2019.
This work was supported by NIH grants R01-AI116814 and R01-AI123342.
The authors declare no conflicts of interest.
E.Z. and S.B.S. wrote the article.
Correspondence: Emmanuel Zorn, Columbia Center for Translational Immunology, Columbia University Medical Center, 630 W 168th St, mailbox 127, New York, NY 10032. (firstname.lastname@example.org).