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Deciphering the Contribution of γδ T Cells to Outcomes in Transplantation

McCallion, Oliver, BMBS1; Hester, Joanna, PhD1; Issa, Fadi, PhD1

doi: 10.1097/TP.0000000000002335
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γδ T cells are a subpopulation of lymphocytes expressing heterodimeric T-cell receptors composed of γ and δ chains. They are morphologically and functionally heterogeneous, innate yet also adaptive in behavior, and exhibit diverse activities spanning immunosurveillance, immunomodulation, and direct cytotoxicity. The specific responses of γδ T cells to allografts are yet to be fully elucidated with evidence of both detrimental and tolerogenic roles in different settings. Here we present an overview of γδ T-cell literature, consider ways in which their functional heterogeneity contributes to the outcomes after transplantation, and reflect on methods to harness their beneficial properties.

A comprehensive overview of the γδ T cell literature, focusing on the ways in which their functional heterogeneity contributes to outcomes after transplantation, and reflection upon methods to harness their beneficial properties.

1 Transplantation Research Immunology Group, University of Oxford, Oxford, United Kingdom.

Received 30 November 2017. Revision received 30 May 2018.

Accepted 31 May 2018.

The authors declare no conflicts of interest.

J.H. is a Kidney Research UK Senior Research Fellow, F.I. is an NIHR Academic Clinical Lecturer.

O.M. performed literature review, designed figures and compiled the article. J.H. compiled and reviewed the figures and the article. F.I. compiled and reviewed the figures and the article.

Correspondence: Joanna Hester, PhD, Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Level 6, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, United Kingdom. (joanna.hester@nds.ox.ac.uk).

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