Articles: PDF OnlyMAJOR HISTOCOMPATIBILITY COMPLEX AND NON-MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS ON MOUSE ECTOPLACENTAL CONE AND PLACENTAL TROPHOBLASTIC CELLS1SELLENS, M. H.; JENKINSON, E. J.; BILLINGTON, W. D. Author Information Reproductive Immunology Research Group, Department of Pathology, The Medical School, University of Bristol, Bristol BS8 1TD, United Kingdom Transplantation: April 1978 - Volume 25 - Issue 4 - p 173-179 Free Abstract SUMMARY The expression of major histocompatibility complex and non-major histocompatibility complex antigens on mouse trophoblast cultured from two defined stages of development was investigated by the sensitive in vitro mixed haemadsorption assay. Outgrowths obtained 3 to 5 days after explanation of 71/2-day ectoplacental cones contained a mixed population of cells. Those with a giant cell morphology showed no haemadsorption with congenic H-2 antisera and were reactive with non-H-2 antiserum only in the CBA strain. Other, smaller cells were reactive for both H-2 and non-H-2 in all strains examined except for C57BL, where the cells were nonreactive for H-2. Monolayer cultures of 13 to 14-day placental suspensions tested 24 hr after preparation were strongly reactive for both H-2 and non-H-2. The identity and alloantigenic status of the cells are discussed in relation to their function in maternal-foetal immunological interactions. © Williams & Wilkins 1978. All Rights Reserved.
