Review ArticlesAdult Glioma WHO Classification Update, Genomics, and Imaging What the Radiologists Need to KnowBai, James MD∗; Varghese, Jerrin MD∗; Jain, Rajan MD∗,†Author Information ∗Department of Radiology, New York University Langone Health, New York, NY †Department of Neurosurgery, New York University Langone Health, New York, NY. Address correspondence to Rajan Jain, MD, Department of Radiology and Neurosurgery, NYU School of Medicine, 660 First Avenue, 2nd Floor, New York, NY 10016 (e-mail: [email protected]). Received 13 December, 2019 Accepted 26 January, 2020 The authors have nothing to disclose. Topics in Magnetic Resonance Imaging: April 2020 - Volume 29 - Issue 2 - p 71-82 doi: 10.1097/RMR.0000000000000234 Buy Metrics Abstract Recent advances in the understanding of the genetic makeup of gliomas have led to a paradigm shift in the diagnosis and classification of these tumors. Driven by these changes, the World Health Organization (WHO) introduced an update to its classification system of central nervous system (CNS) tumors in 2016. The updated glioma classification system incorporates molecular markers into tumor subgrouping, which has been shown to better correlate with tumor biology and behavior as well as patient prognosis than the previous purely histology-based classification system. Familiarity with this new classification scheme, the individual molecular markers, and corresponding imaging findings is critical for the radiologists who play an important role in diagnostic and surveillance imaging of patients with CNS tumors. The goals of this article are to review these updates to the WHO classification of CNS tumors with a focus on adult gliomas, provide an overview of key genomic markers of gliomas, and review imaging features pertaining to various genomic subgroups of adult gliomas. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.