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The State of Resting State Networks

Seitzman, Benjamin A. BS*; Snyder, Abraham Z. MD, PhD; Leuthardt, Eric C. MD‡,§; Shimony, Joshua S. MD, PhD

Topics in Magnetic Resonance Imaging: August 2019 - Volume 28 - Issue 4 - p 189–196
doi: 10.1097/RMR.0000000000000214
Review Articles
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Functional MRI (fMRI) is currently used for pre-surgical planning, but is often limited to information on the motor and language systems. Resting state fMRI can provide more information on multiple other networks to the neurosurgeon and neuroradiologist; however, currently, these networks are not well known among clinicians. The purpose of this manuscript is to provide an introduction to these networks for the clinician and to discuss how they could be used in the future for precise and individualized surgical planning. We provide a short introduction to resting state fMRI and discuss multiple currently accepted resting state networks with a review of the literature. We review the characteristics and function of multiple somatosensory, association, and other networks. We discuss the concept of critical nodes in the brain and how the neurosurgeon can use this information to individually customize patient care. Although further research is necessary, future application of pre-surgical planning will require consideration of networks other than just motor and language in order to minimize post-surgical morbidity and customize patient care.

*Department of Neurology, Washington University School of Medicine, St. Louis, MO

Mallinckrodt Institute of Radiology, St. Louis, MO

Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO

§Department of Biomedical Engineering, Washington University School of Medicine, St. Louis, MO.

Address correspondence to Joshua S. Shimony, MD, PhD, Washington Univ. School of Medicine, Campus Box 8131, 510 S. Kingshighway Blvd., St. Louis, MO 63110 (e-mail: shimonyj@gmail.com).

Received 14 April, 2019

Accepted 3 June, 2019

This project was supported by the National Institute of Health grants: R01 CA203861, and U54 HD087011 to the Intellectual and Developmental Disabilities Research Center at Washington University.

The authors report no conflicts of interest

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