In congenital Zika virus syndrome (CZS), the most frequent radiological findings are calcifications in the cortical–white matter junction and malformations of cortical development (pachygyria or polymicrogyria, which occur predominantly in the frontal lobes, or a simplified gyral pattern), ventriculomegaly, enlargement of the cisterna magna and the extra-axial subarachnoid space, corpus callosum abnormalities, and reduced brain volume. This syndrome can also result in a decrease in the brainstem and cerebellum volumes and delayed myelination. Infants with CZS may show venous thrombosis and lenticulostriate vasculopathies. Over a 3-year follow-up period, many infants with CZS showed hydrocephalus, reduction in brain calcifications, and greater reduction in brain thickness.
*Multimagem, Recife, Brazil
†Catholic University of Pernambuco, Recife, Brazil
‡Barão de Lucena Hospital, Recife, Brazil
§Federal University of Pernambuco, Recife, Brazil
||Royal Perth Hospital (RPH)
¶University of Western Australia (UWA) Medical School, Perth, WA, Australia.
Address correspondence to Maria de Fatima Viana Vasco Aragao, MD, PhD, Rua Frei Matias Teves, 194 - Ilha do Leite, Recife - PE, 50070-450, Brazil (e-mail: email@example.com).
The authors report no conflicts of interest.