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Updated Imaging Findings in Congenital Zika Syndrome

A Disease Story That is Still Being Written

Aragao, Maria de Fatima Viana Vasco, MD, PhD*,†; Petribu, Natacha Calheiros de Lima, MD, MSc; van der Linden, Vanessa, MD, MSc; Valenca, Marcelo Moraes, MD, PhD§; Brito, Carlos Alexandre Antunes de, MD, PhD§; Parizel, Paul M., MD, PhD||,¶

Topics in Magnetic Resonance Imaging: February 2019 - Volume 28 - Issue 1 - p 1–14
doi: 10.1097/RMR.0000000000000193
Review Articles

In congenital Zika virus syndrome (CZS), the most frequent radiological findings are calcifications in the cortical–white matter junction and malformations of cortical development (pachygyria or polymicrogyria, which occur predominantly in the frontal lobes, or a simplified gyral pattern), ventriculomegaly, enlargement of the cisterna magna and the extra-axial subarachnoid space, corpus callosum abnormalities, and reduced brain volume. This syndrome can also result in a decrease in the brainstem and cerebellum volumes and delayed myelination. Infants with CZS may show venous thrombosis and lenticulostriate vasculopathies. Over a 3-year follow-up period, many infants with CZS showed hydrocephalus, reduction in brain calcifications, and greater reduction in brain thickness.

*Multimagem, Recife, Brazil

Catholic University of Pernambuco, Recife, Brazil

Barão de Lucena Hospital, Recife, Brazil

§Federal University of Pernambuco, Recife, Brazil

||Royal Perth Hospital (RPH)

University of Western Australia (UWA) Medical School, Perth, WA, Australia.

Address correspondence to Maria de Fatima Viana Vasco Aragao, MD, PhD, Rua Frei Matias Teves, 194 - Ilha do Leite, Recife - PE, 50070-450, Brazil (e-mail:

The authors report no conflicts of interest.

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