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Diffusion Quantification in Body Imaging

Taffel, Myles T. MD; Johnson, Evan J. MD; Chandarana, Hersh MD

Topics in Magnetic Resonance Imaging: December 2017 - Volume 26 - Issue 6 - p 243–249
doi: 10.1097/RMR.0000000000000144
Review Articles

Diffusion-weighted imaging (DWI) is increasingly incorporated into routine body magnetic resonance imaging protocols. DWI can assist with lesion detection and even in characterization. Quantitative DWI has exhibited promise in the discrimination between benign and malignant pathology, in the evaluation of the biologic aggressiveness, and in the assessment of the response to treatment. Unfortunately, inconsistencies in DWI acquisition parameters and analysis have hampered widespread clinical utilization. Focusing primarily on liver applications, this article will review the basic principles of quantitative DWI. In addition to standard mono-exponential fitting, the authors will discuss intravoxel incoherent motion and diffusion kurtosis imaging that involve more sophisticated approaches to diffusion quantification.

Department of Radiology, New York University School of Medicine, New York, NY.

Address correspondence to Myles T. Taffel, MD, Department of Radiology, New York University School of Medicine, 660 First Avenue; 3rd Floor, New York, NY 10016 (e-mail:

The authors report no conflicts of interest.

Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.