Review ArticlesCT-based Techniques for Brain PerfusionKrishnan, Pradeep MD*,†; Murphy, Amanda MD‡; Aviv, Richard I. MD, FRCR‡Author Information *Division of Neuroradiology, Department of Medical Imaging, University of Toronto and Sunnybrook Health Sciences Centre †Diagnostic Imaging, The Hospital for Sick Children ‡Division of Neuroradiology, Department of Medical Imaging, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Address correspondence to Richard I. Aviv, MD, FRCR, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada. (e-mail: [email protected]). Pradeep Krishnan, Amanda Murphy, and Richard I. Aviv contributed equally to the manuscript. The authors report no conflicts of interest. Topics in Magnetic Resonance Imaging: June 2017 - Volume 26 - Issue 3 - p 113-119 doi: 10.1097/RMR.0000000000000129 Buy Metrics Abstract Recent rapid advances in endovascular treatment for acute ischemic stroke highlight the crucial role of neuroimaging especially multimodal computed tomography (CT) including CT perfusion in stroke triage and management decisions. With an increasing focus on changes in cerebral physiology along with time-based matrices in clinical decisions for acute ischemic stroke, CT perfusion provides a rapid and practical modality for assessment and identification of salvageable tissue at risk and infarct core and provides a better understanding of the changes in cerebral physiology. Although there are challenges with the lack of standardization and accuracy of quantitative assessment, CT perfusion is evolving as a cornerstone for imaging-based strategies in the rapid management of acute ischemic stroke. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.