Review ArticlesImaging Genomics of Glioblastoma Biology, Biomarkers, and BreakthroughsMoton, Safwan MS*; Elbanan, Mohamed MD*; Zinn, Pascal O. MD, PhD†; Colen, Rivka R. MD*‡Author Information From the *Department of Diagnostic and Radiology, University of Texas, MD Anderson Cancer Center; †Department of Neurosurgery and Baylor College of Medicine; and ‡ Department of Cancer Systems Imaging, University of Texas, MD Anderson Cancer Center, Houston, TX. Correspondence to Rivka R. Colen, MD, Department of Radiology, MD Anderson Cancer Center, 1400 Pressler Street, Unit 1482, Houston, TX 77030 (e-mail: [email protected]). The authors declare no conflict of interest. Topics in Magnetic Resonance Imaging: June 2015 - Volume 24 - Issue 3 - p 155-163 doi: 10.1097/RMR.0000000000000052 Buy Metrics Abstract Glioblastoma is regarded as the most aggressive and most common primary malignant brain tumor in adults. Despite advancements in chemotherapy and radiotherapy, prognosis and overall survival of glioblastoma patients remain dismal. Recently, progresses in genetic profiling have increased our understanding of the underlying heterogenous molecular nature of this aggressive tumor. Several prognostic and predictive molecular biomarkers have been identified that have been linked to patient’s survival and response to treatment, respectively. Imaging genomics represents a novel entity in clinical sciences that bidirectionally links imaging features with underlying molecular profile and thus can serve as a surrogate for noninvasive genomic correlation, prediction, and identification. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.