Original ArticlesAdvanced Magnetic Resonance Imaging Techniques in the Evaluation of Pediatric White Matter DiseasesRueda-Lopes, Fernanda Cristina MD, MSc; Doring, Thomas Martin MSc; Gasparetto, Emerson Leandro MD, PhDAuthor Information From the Department of Radiology (Neuroradiology), University Federal of Rio de Janeiro and CDPI—Clínica de Diagnóstico por Imagem/DASA, Rio de Janeiro, Brazil. Reprints: Emerson L. Gasparetto, MD, PhD, Estrada da Barra da Tijuca, 1006, Bl 5, Apt 1106, 22641-003 Rio de Janeiro-RJ, Brazil (email: firstname.lastname@example.org). The authors declare no conflict of interest. Topics in Magnetic Resonance Imaging: October 2011 - Volume 22 - Issue 5 - p 251–258 doi: 10.1097/RMR.0b013e3182972aa1 Buy Metrics Abstract This article aimed to describe the technical principles and clinical application of advanced magnetic resonance imaging techniques for the assessment of white matter diseases. The following techniques are going to be discussed: magnetization transfer, proton magnetic resonance spectroscopy, diffusion-weighted imaging, diffusion tensor imaging, as well as perfusion and postprocessing techniques such as tract-based spatial statistics. These techniques allow a better understanding of the physiopathology of the white matter diseases as well as have a significant impact on the definition of the differential diagnosis and treatment options. © 2011 Lippincott Williams & Wilkins, Inc.