Original ArticlesCortical Development in the Fetus and the Newborn: Advanced MR TechniquesHüppi, Petra S. MDAuthor Information From the Division of Development and Growth, Department of Pediatrics, Geneva University Hospitals, Geneva, Switzerland. Reprints: Petra S. Hüppi, MD, Service Développement et Croissance, Department Enfant et Adolescent, Hôpital des Enfants des HUG, 1211 Genève 14, Switzerland (e-mail: firstname.lastname@example.org). Disclosure: The author declares no conflict of interest. Topics in Magnetic Resonance Imaging: February 2011 - Volume 22 - Issue 1 - p 33–38 doi: 10.1097/RMR.0b013e3182416f78 Buy Metrics Abstract Brain function is tightly linked to the development of the cortex. Until recently, assessing the human cortical development and folding was not possible in vivo. It is magnetic resonance imaging and new post-processing image analysis tools that have improved the understanding of cortical development. The combination of conventional magnetic resonance imaging and diffusion tensor imaging has further allowed depiction of the relationship of changes in intracortical layering and cortical folding. Being able to follow these early developmental processes has elucidated changes in early brain development due to changed environmental conditions in fetal life such as twinning and fetal growth restriction and postnatal conditions such as prematurity. This review further illustrates new data on brain structural asymmetries linked to the emergence of early language functions. © 2011 Lippincott Williams & Wilkins, Inc.