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Motor, Cognitive, and Behavioral Performance in Middle-Aged and Older Adults With Multiple Sclerosis

Saymuah, Sara BS; Laird, Hayley BS; Nitta, Manon BA; Atalla, Mareena BA; Fritz, Nora E. PhD, PT, DPT, NCS

doi: 10.1097/TGR.0000000000000235
Aging With a Progressive Neurologic Disease

Age-related changes in motor function from young to old age in persons with multiple sclerosis (MS) have been well-documented. However, little is known about motor, cognitive, and behavioral differences between middle-aged and older adults with MS, and global relationships among motor, cognitive, and behavioral factors in persons with MS. In this study, we recruited ambulatory middle-aged and older adults with MS to complete walking, dual-task, cognitive, and survey measures. We found no differences in performance between groups in our sample of mildly disabled individuals with MS, suggesting that individuals with mild disease may have reduced age-related declines in motor function.

Neuroimaging and Neurorehabilitation Laboratory (Mss Saymuah, Laird, Nitta, and Atalla and Dr Fritz) and Program in Physical Therapy and Department of Neurology (Dr Fritz), Wayne State University, Detroit, Michigan.

Correspondence: Nora E. Fritz, PhD, PT, DPT, NCS, Wayne State University, 259 Mack Av, #2324, Detroit, MI 48201 (

The authors gratefully acknowledge all of our participants as well as Carla Santiago for her assistance with study coordination and Eva Bernitsas, Bob Lisak, and Dequanna Johnson for assistance with participant recruitment.

The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article.

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