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Effects of Aerobic Exercise on Electrophysiological Features of Diabetic Peripheral Neuropathy

Single-Blind Clinical Trial

Azizi, Sirous, MD; Najafi, Sharif, MD; Rezasoltani, Zahra, MD; Sanati, Ehsan, MD; Zamani, Nahid, MD; Dadarkhah, Afsaneh, MSc

Topics in Geriatric Rehabilitation: April/June 2019 - Volume 35 - Issue 2 - p 164–169
doi: 10.1097/TGR.0000000000000229
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Objective: To investigate electrophysiological effects of exercise on peripheral neuropathy in patients with type 2 diabetes mellitus.

Methods: Thirty-five patients (21 women) with diabetic peripheral neuropathy were included with mean (SD) age of 56.9 (6.2) years. We performed electrophysiological studies, and after 8 weeks of exercise, reevaluated the participants.

Results: Sural sensory nerve (P < .001) and tibial compound muscle (P = .001) action potential increased, while F-wave (P = .024) and nerve conduction velocity (P = .001) decreased significantly. Conduction velocity for deep peroneal nerve showed a significant increase (P = .001).

Conclusion: Aerobic exercise improves electrophysiological features and should be considered in the therapy of diabetic peripheral neuropathy.

Department of Physical Medicine and Rehabilitation, Aja University of Medical Sciences, School of Medicine, Tehran, Islamic Republic of Iran.

Correspondence: Afsaneh Dadarkhah, MSc, Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Aja University of Medical Sciences, Etemadzadeh St, Western Fatemi, Tehran, Postal Code: 1411718541, Islamic Republic of Iran (

The authors thank the physiotherapists of Imam Reza Hospital for their collaboration, and their colleagues from Rehabilitation and Biomechanics Research Center of the Aja University of Medical Sciences for their invaluable assistance.

The authors declare that they have no competing interests.

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