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Physical Exercise and Cognitive Training Clinical Interventions Used in Slowing Degeneration Associated With Mild Cognitive Impairment: A Review of the Recent Literature

Amoyal, Nicole MS; Fallon, Elizabeth PhD

doi: 10.1097/TGR.0b013e31825fc8d3
Special Features

Recent literature provides empirical evidence for nonpharmacologic interventions' potential to slow degeneration associated with mild cognitive impairment. Physical exercise and cognitive training interventions have showed trending toward slowing degenerative processes associated with dementia, specifically related to plasticity. A review of 6 clinical trials (2 physical exercise and 4 cognitive training) showing trending toward slowing degenerative processes in mild cognitive impairment is provided. Brain and metabolic changes associated with plasticity were associated with neuropsychological test performance. Several strengths, limitations, and suggestions for future empirical research were offered. Nonpharmacologic interventions should continue to be developed and tested via clinical trials with mild cognitive impairment patients.

Cancer Prevention Research Center, University of Rhode Island, Kingston.

Correspondence: Nicole Amoyal, MS, University of Rhode Island, 2 Chafee Road, Kingston, RI 02881 (

None of the investigators in this study have a possible conflict of interest, financial or otherwise.

© 2012 Lippincott Williams & Wilkins, Inc.