ORIGINAL ARTICLEThe Relationship Between Exogenous Testosterone and Resting Energy Expenditure in Adults A Systematic ReviewRoop, Karen MS, RDN; Coakley, Kathryn E. PhD, RDN; Cohen, Deborah DCN, RDN; Gonzales-Pacheco, Diana DCN, RDN Author Information Department of Individual, Family, and Community Education, University of New Mexico, Albuquerque (Ms Roop and Drs Coakley and Gonzales-Pacheco); and Department of Clinical and Preventive Nutrition Sciences, Rutgers University, Newark, New Jersey (Dr Cohen). Correspondence: Diana Gonzales-Pacheco, DCN, RDN, Department of Individual, Family, and Community Education, University of New Mexico, Albuquerque, NM 87131 ([email protected]). The authors thank Jean Cerami, MS, RDN, for critically reviewing the manuscript. The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (http://topicsinclinicalnutrition.com). Topics in Clinical Nutrition 38(2):p 161-172, April/June 2023. | DOI: 10.1097/TIN.0000000000000318 Buy SDC Metrics Abstract A systematic review was conducted to investigate the association between exogenous testosterone therapy and resting energy expenditure (REE) in adults. Eleven studies met the inclusion criteria (n = 259; 93% male). Results of this systematic review indicate that exogenous testosterone does not significantly affect REE. Registered dietitian nutritionists (RDNs) may not need to adjust individual energy needs based solely on exogenous testosterone therapy. However, this systematic review is limited because of the paucity of studies addressing this topic. RDNs should consider the most current published research regarding use of exogenous testosterone in adults when assessing REE in patients receiving exogenous testosterone therapy. © 2023 Wolters Kluwer Health, Inc. All rights reserved.