Effects of Resveratrol Supplementation on Nonalcoholic Fatty Liver Disease Management: An Updated Systematic Review and Meta-analysis : Topics in Clinical Nutrition

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ORIGINAL ARTICLE

Effects of Resveratrol Supplementation on Nonalcoholic Fatty Liver Disease Management

An Updated Systematic Review and Meta-analysis

Nemati, Arefe MSc; Nikniaz, Zeinab PhD; Mota, Ali PhD

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Topics in Clinical Nutrition 38(2):p 144-160, April/June 2023. | DOI: 10.1097/TIN.0000000000000314

Abstract

In this study, we aimed to systematically review the studies that investigated the effect of resveratrol in nonalcoholic fatty liver disease (NAFLD). A systematic search of different databases was conducted until June 2021 and a meta-analysis was completed.

Six trials involving 232 participants were included. The meta-analysis results showed that serum triglycerides (P = .04), interleukin-6 (P = .01), tumor necrosis factor-α (P = .02), and systolic blood pressure (P = .04) levels were decreased significantly in the resveratrol group compared with the placebo group, while other parameters were not changed significantly. Although resveratrol might attenuate NAFLD development, more high-quality trials are required in this field.

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