ORIGINAL ARTICLEThe Use of the RELiZORB Immobilized Lipase Cartridge in Enterally-Fed Children With Cystic Fibrosis A Retrospective Case SeriesBaghae Pour, Parasto MS, RDN, LD; Gregg, Shannon MS, RDN, LD; Coakley, Kathryn E. PhD, RDN; Caffey, L. Francine MD; Cohen, Deborah DCN, RDN; Myers, Orrin B. PhD; Gonzales-Pacheco, Diana DCN, RDN Author Information Department of Individual, Family, and Community Education, University of New Mexico, Albuquerque (Ms Baghae Pour and Drs Coakley and Gonzales-Pacheco); Departments of Pediatrics Pulmonary (Ms Gregg and Dr Caffey) and Family and Community Medicine (Dr Myers), University of New Mexico Health Sciences Center, Albuquerque; and Department of Clinical and Preventive Nutrition Sciences, Rutgers University, Newark, New Jersey (Dr Cohen). Correspondence: Diana Gonzales-Pacheco, DCN, RDN, College of Education and Human Sciences, Department of Individual, Family, and Community Education, MSC05 3042, 1 University of New Mexico, Albuquerque, NM 87131 ([email protected]). The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. Topics in Clinical Nutrition: October/December 2022 - Volume 37 - Issue 4 - p 266-275 doi: 10.1097/TIN.0000000000000300 Buy Metrics Abstract The objective of this retrospective study was to evaluate the impact of the RELiZORB immobilized lipase cartridge with overnight enteral nutrition (EN) on body mass index (BMI) or weight-for-length percentile, stool quality, and gastrointestinal (GI) symptoms in children with cystic fibrosis (CF) and pancreatic insufficiency. Frequency of diarrhea, steatorrhea, and malodorous stools significantly decreased at final visit compared with baseline (P = .008, P = .004, P = .031, respectively). Improved BMI or weight-for-length percentile was observed in 10 out of 16 participants; however, the change was not significant. RELiZORB use decreased frequency of most GI symptoms in pediatric patients with CF on EN. © 2022 Wolters Kluwer Health, Inc. All rights reserved.