REVIEW ARTICLEImpact of Prebiotics, Probiotics, and Synbiotics on Stool Output, Mortality, and Recovery in the Critically Ill A Literature ReviewChin, Haley J. MS, RDN, LD/N; Yu, Zhiping PhD, RDN, LD/N Author Information Department of Nutrition and Dietetics, University of North Florida, Jacksonville. Correspondence: Haley J. Chin, MS, RDN, LD/N, Department of Nutrition and Dietetics, University of North Florida, 1 UNF Dr, Jacksonville, FL 32224 ([email protected]). The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. Topics in Clinical Nutrition: October/December 2022 - Volume 37 - Issue 4 - p 338-349 doi: 10.1097/TIN.0000000000000299 Buy Metrics Abstract This study reviewed the research published between 2010 and 2020 on application and usage of prebiotics, probiotics, and synbiotics on stool output, mortality, and recovery in critically ill patients. A total of 15 articles were retrieved and 11 were identified for review. Among studies addressing stool output, 4 of 7 reported improved outcomes. No statistically significant effect of the intervention was seen in 5 studies addressing mortality. Concerning elements of recovery, positive evidence was seen in the areas of return to gut function, time on mechanical ventilation, time to ventilator weaning, and length of stay in intensive care unit and/or hospital. © 2022 Wolters Kluwer Health, Inc. All rights reserved.