NARRATIVE REVIEWNavigating the Maze of Dietary Supplements Quality and EfficacyO'Dwyer, Darla Daniel PhD, RDAuthor Information Stephen F. Austin State University, School of Human Sciences, Nacogdoches, Texas. Correspondence: Darla Daniel O'Dwyer, PhD, RD, Stephen F. Austin State University, School of Human Sciences, Box 13014-SFA Station, Nacogdoches, TX 75962 (firstname.lastname@example.org). Darla Daniel O'Dwyer conceived of and wrote the manuscript. The author thanks Sujatha Vegiraju for her research assistance. The author has disclosed that she has no significant relationships with, or financial interest in, any commercial companies pertaining to this article. Topics in Clinical Nutrition: October/December 2020 - Volume 35 - Issue 4 - p 309-319 doi: 10.1097/TIN.0000000000000214 Buy Metrics Abstract Over half of the adult population consumes dietary supplements, according to one estimate. Choosing the right form of supplements based on the physiology of the patient, genetic variability (if possible), and lifestyle factors are important. Some supplements have poor bioavailability based on the chemical nature of an ingredient. These products should either be combined with ingredients or processed in a way to enhance bioavailability. The supplement should be able to disintegrate and dissolve in a specific amount of time. Knowledge of inactive ingredients is recommended to avoid unintended side effects. Suggestions to assist in the supplement evaluation process are provided. © 2020 Wolters Kluwer Health, Inc. All rights reserved.