NARRATIVE REVIEWNavigating the Maze of Dietary Supplements Regulation and SafetyO'Dwyer, Darla Daniel PhD, RD; Vegiraju, Sujatha MS, RDAuthor Information School of Human Sciences, Stephen F. Austin State University, Nacogdoches, Texas. Correspondence: Darla Daniel O'Dwyer, PhD, RD, School of Human Sciences, Stephen F. Austin State University, Box 13014-SFA Station, Nacogdoches, TX 75962 (firstname.lastname@example.org). D. O'Dwyer conceived of and wrote the first manuscript draft and edited the final draft. S. Vegiraju provided invaluable research contributions and first draft revisions. The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. Topics in Clinical Nutrition: July/September 2020 - Volume 35 - Issue 3 - p 248-263 doi: 10.1097/TIN.0000000000000207 Buy Metrics Abstract Dietary supplement companies must adopt Current Good Manufacturing Practices (cGMPs) to ensure that procedures are in place in order to verify the identity, strength, purity, and composition of supplement ingredients. In addition to the Food and Drug Administration enforcement, independent regulatory agencies exist to verify cGMP compliance. Supplement companies must follow regulations governing claims, labeling, advertising, and packaging. The safety record of dietary supplements and resources to assess drug nutrient interactions are discussed. Understanding the regulatory and safety issues surrounding dietary supplements will help nutrition professionals have more confidence when recommending them as an adjunct to diet and lifestyle. © 2020 Wolters Kluwer Health, Inc. All rights reserved.