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Development of an At-Risk Score for Metabolic Syndrome

Olfert, Melissa D. DrPH, RDN; Clark, Rashel L. MS, RDN; Famodu, Oluremi A. PhD, RDN; Murray, Pamela J. MD; Olfert, I. Mark PhD; Downes, Marianne T. PhD; McFadden, Joseph W. PhD; Cuff, Christopher F. PhD; Colby, Sarah E. PhD, RDN; Morrell, Jesse S. PhD

doi: 10.1097/TIN.0000000000000188

To develop and validate a metabolic syndrome (MetS) risk score, young adults completed an in-person assessment and online health history questionnaire. Risk scoring was based on weighted multivariate risk score functions. The area under the curve was 0.86 (95% CI, 0.32 to 0.81), indicating a significant relationship between higher scores and increased odds of MetS diagnosis (OR = 1.7; 95% CI, 1.38 to 2.25). The new score was associated with the MetS Severity Score (r [correlation coefficient] = 0.42; 95% CI, 0.31 to 0.51; P < .0001) and the American Heart Association score (r = −0.49; 95% CI, −0.57 to −0.39; P < .0001). This score can help improve primary prevention intervention strategies for young adults at risk of MetS.

Division of Animal and Nutritional Sciences, Davis College of Agriculture, Natural Resources and Design (Drs Olfert and Famodu and Ms Clark), Department of Pediatrics (Dr Murray), School of Medicine (Drs Olfert, Downes, and Cuff), and Department of Pathology (Downes), West Virginia University, Morgantown; Department of Pediatrics, Section of Adolescent Medicine, West Virginia Clinical and Translational Science Institute, Morgantown (Dr Murray); Department of Animal Sciences, Cornell University, Ithaca, New York (Dr McFadden); Department of Nutrition, University of Tennessee, Knoxville (Dr Colby); and Department of Agriculture, Nutrition, and Food Systems, University of New Hampshire, Durham (Dr Morrell).

Correspondence: Melissa D. Olfert, DrPH, RDN, Division of Animal and Nutritional Sciences, Davis College of Agriculture, Natural Resources, and Design, West Virginia University, G25 Agriculture Sciences Bldg, 333 Evansdale Dr, Morgantown, WV 26506 (

Author Contributions: Conceptualization: M.D.O., P.J.M.; data curation: M.D.O., J.S.M.; formal analyses: R.L.C.; writing—original draft preparation: R.L.C., M.D.O.; writing—review and editing: M.D.O., R.L.C., O.A.F., P.J.M., I.M.O., M.T.D., J.W.M., C.F.C., S.E.C., J.S.M; funding acquisition: M.D.O., I.M.O., P.J.M., S.E.C.

This work was funded by the following grants: USDA/AFRI #2014-67001-21851; WVU Hatch WVA00641; WV Clinical and Translational Science Institute (NIH/MIGMS Award no. U54GM104942); WVU Mountains of Excellence Pilot Grant Program; and WVU Pediatrics Department Grant.

The authors thank the research team at the University of New Hampshire for the collection of validation data, and Timothy Waanders and Chris Molina for assisting the graduate researchers with the calculation scores of both WVU and UNH data. Furthermore, the authors thank the statisticians Drs Ida Haloskova and Christa Lilly for their assistance.

The data sets used and analyzed during the current study are available from the corresponding author on reasonable request.

The authors declare no conflicts of interest.

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