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The Role of Perilipins in the Development of Obesity and Obesity-Related Diseases

Nicolaidou, Katerina RDN; Isoldi, Kathy K. PhD, RD; Ramer, Nicholas J. PhD; Sarcona, Alessandra EdD, RD

doi: 10.1097/TIN.0000000000000078
Current Research for Practitioners

Understanding nonmodifiable factors promoting weight gain can help clinicians reduce their bias and improve patient care. This review outlines research linking perilipins with the regulation of body fat. Perilipins are proteins that coat lipid droplets. There are 5 known perilipins with varying functions, and perilipin 1 is the most widely researched of all. Rodent studies found a strong link between perilipin 1 and increased fat mass; however, studies with human subjects found inconsistencies, perhaps because of sex and genetic variations. Although some inconsistencies are evident, an association between perilipins and the development of obesity has been established.

Long Island University, Brookville, New York.

Correspondence: Kathy K. Isoldi, PhD, RD, Department of Nutrition, Assistant Professor, Long Island University/Post, 720 Northern Blvd, Brookville, NY 11548 (

The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article.

Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.