REVIEWSDo the Micronutrients Zinc and Magnesium Play a Role in Adult Depression?Dickerman, Barbra; Liu, Jianghong PhDAuthor Information Department of Family and Community Health, School of Nursing, University of Pennsylvania, Philadelphia. Correspondence: Barbra Dickerman, Department of Family and Community Health, School of Nursing, University of Pennsylvania, 418 Curie Blvd, Clare M. Fagin Hall, Philadelphia, PA 19104 ([email protected]). The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. Topics in Clinical Nutrition: July/September 2011 - Volume 26 - Issue 3 - p 257-267 doi: 10.1097/TIN.0b013e3182260d86 Buy Metrics Abstract Depression is a widespread disorder that affects more than 120 million people worldwide. The unsatisfactory clinical efficacy and adverse effects of antidepressant medication have prompted the search for novel treatments. Micronutrient deficiencies may play a role in the development of depression, and recent research studies have explored the use of micronutrient supplementation as an adjunct to the pharmacotherapy of this psychiatric illness. This article provides a review of the empirical evidence linking zinc and magnesium deficiency and depression, discusses possible mechanisms of action in the psychopathology and therapy of depression, and explores the nursing and registered dietitian implications of these findings. © 2011 Lippincott Williams & Wilkins, Inc.