Reports of ResearchWasting Disease, Chronic Immune Activation, and Inflammation in the HIV-Infected PatientWasserman, Peter RD, MA; Segal-Maurer, Sorana MD; Wehbeh, Wehbeh MD; Rubin, David S. MDAuthor Information Infectious Disease Division, Department of Medicine, New York Hospital Queens, Flushing (Mr Wasserman and Drs Segal-Maurer, Wehbeh, and Rubin); and Weill Cornell Medical College, New York (Drs Segal-Maurer, Wehbeh, and Rubin). Peter Wasserman, RD, MA, Infectious Disease Division, Department of Medicine, New York Hospital Queens, Flushing, NY 11355 (firstname.lastname@example.org). Topics in Clinical Nutrition: January/March 2011 - Volume 26 - Issue 1 - p 14-28 doi: 10.1097/TIN.0b013e318209e3a0 Buy Metrics Abstract HIV infection leads to ongoing immune activation and inflammation within gut-associated lymphoid tissue. Host response initiates events that participate in CD4+ T cell depletion and soft-tissue wasting. Chronic immune activation is associated with disruption of organized lymphoid tissue and gut-barrier integrity, and microbial translocation that may impact whole-body energy metabolism and protein turnover. Systemic stress leading to decreased food intake and/or viral damage to endocrine tissue is associated with wasting disease in HIV-infected patients. Clinical management requires appreciation of subjective, physical, and biochemical parameters, as well as addressing factors associated with food insecurity. © 2011 Lippincott Williams & Wilkins, Inc.