DIETETIC RESEARCH PROJECTEffects of Dietary and Supplemental Forms of Isoflavones on Thyroid Function in Healthy Postmenopausal WomenRyan-Borchers, Tracy PhD, RD; Chew, Boon PhD; Park, Jean Soon PhD; McGuire, Michelle PhD; Fournier, Lisa PhD; Beerman, Kathy PhD Author Information Department of Nutrition, Oregon Health Science University, Portland, Oregon (Dr Ryan-Borchers); and Departments of Food Science and Human Nutrition (Drs Chew, Park, McGuire, and Beerman) and Psychology (Dr Fournier), Washington State University, Pullman. Corresponding author: Kathy Beerman, PhD, Department of Food Science and Human Nutrition, Washington State University, Pullman, WA 99164 ([email protected]). Funding for this study was provided, in part, by a grant from the Washington State Attorney General Office. The authors express their appreciation to the study participants for all their hard work. We all extend gratitude to White Wave, Inc, and Archer Daniel Midland for their contributions to the study. Topics in Clinical Nutrition: January 2008 - Volume 23 - Issue 1 - p 13-22 doi: 10.1097/01.TIN.0000312076.38329.55 Buy Metrics Abstract Because of the health concerns associated with hormone replacement therapy, many women are seeking alternative therapies. Compounds such as soy isoflavones appear to reduce the risk of some age-related diseases and to lessen the severity of menopausal symptoms. However, concerns regarding harmful effects of soy isoflavones on thyroid function have been reported. This 16-week, double-blinded, placebo-controlled trial evaluated the effects of soy isoflavones on thyroid-stimulating hormone in healthy postmenopausal women. The results of this study suggest that isoflavones obtained from either soymilk or supplements have no effect on thyroid-stimulating hormone in well-nourished postmenopausal women. © 2008 Lippincott Williams & Wilkins, Inc.