INSTRUCTIONS Rheumatoid arthritis: New treatments, better outcomes
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Rheumatoid arthritis: New treatments, better outcomes
General Purpose: The purpose of this learning activity is to provide information about advances in treating RA. Learning Objectives: After reading this article and taking the test, the learner will be able to: 1. Identify current practice recommendations for treating RA. 2. Discuss new drug therapies for RA.
- In comparison to previous criteria, the 2010 RA classification criteria
- reduced sensitivity but improved specificity.
- improved sensitivity but reduced specificity.
- improved both sensitivity and specificity.
- reduced both sensitivity and specificity.
- For clinical trials, the Boolean-based definition of RA remission includes a C-reactive protein level of
- ≤ 1.0 mg/dL.
- ≤ 1.8 mg/dL.
- ≤ 2.2 mg/dL.
- ≤ 3.3 mg/dL.
- Guidelines recommend that to prevent joint damage, appropriate drug therapy should begin within how long after diagnosis?
- 1 week
- 1 month
- 3 months
- 1 year
- Using the treat-to-target criteria, how often should medications be adjusted until the target is met?
- each week
- each month
- every 2 months
- at least every 3 months
- All of the following indicate potential for a poor prognosis except
- erosions on radiography.
- functional limitations.
- extra-articular disease.
- need for DMARD therapy.
- What is the first line of therapy for moderate-to-severe RA?
- According to Finckh and colleagues, evidence for the cost-effectiveness of using biologic agents as an early therapy is
- highly significant.
- Which FDA-approved drug do the authors not recommend due to limited effectiveness?
- Which of the following drugs is an anti-TNF alpha agent?
- Radstake and colleagues found that some patients who take anti-TNF alpha agents
- develop serum antibodies to the drug.
- are at risk for tumor lysis syndrome.
- are at risk for cardiovascular disease.
- develop hypercholesterolemia.
- Which anti-TNF alpha agent has the longest half-life?
- certolizumab pegol
- Tocilizumab is an example of a(an)
- anti-TNF alpha agent.
- Beta-cell inhibitor.
- IL-6 receptor inhibitor.
- IL-6 agonist.
- Which drug is a beta-cell inhibitor that has FDA approval for patients who fail to respond well to anti-TNF alpha agents?
- certolizumab pegol
- Taking certolizumab pegol or golimumab presents a risk of reactivating TB and
- hepatitis B.
- hepatitis C.
- herpes zoster.
- pulmonary fibrosis.
- Which of the following is contraindicated during tocilizumab therapy?
- tuberculin skin testing
- co-therapy with methotrexate
- live or attenuated vaccinations
- treatment with antibiotics
- The ACR indicates that patients with RA and hepatitis C can be treated with
- Before beginning therapy with biologic agents, the ACR recommends screening all patients for
- latent TB.
- hepatitis B antibodies.
- hepatitis C infection.
- demyelinating diseases.
- Which score on the ACR/EULAR criteria for RA indicates an RA diagnosis?
- < 6
- ≥ 6
- ≥ 12