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U-500 concentrated regular insulin: Practical application in the outpatient setting

Taylor, Sarah CNP, MSN, CDE

doi: 10.1097/01.NPR.0000418384.83735.7c

Administering large insulin doses to patients with severely insulin-resistant diabetes is often ineffective, expensive, and painful. U-500 regular insulin is absorbed better, less painful, and more cost-effective due to the reduced volume. This article describes the most recent guidelines for U-500 insulin in the clinical setting.

Sarah Taylor is a clinical nurse practitioner at The Ohio State University Medical Center, Division of Endocrinology, Diabetes, and Metabolism.

The author has disclosed no financial relationships related to this article.

© 2012 Lippincott Williams & Wilkins, Inc.