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Published ahead-of-print in JTI is an original article entitled “Defining Left Ventricular Noncompaction Using Cardiac Computed Tomography” by MS Sidhu and colleagues at Massachusetts General Hospital. The authors retrospectively analyzed CT images of 8 patients with left ventricular noncompaction (LVNC), 11 patients with hypertrophic cardiomyopathy, 9 patients with severe aortic regurgitation, 10 patients with left ventricular hypertrophy from essential hypertension, and 20 normal controls.
Using qualitative analysis, 17 myocardial segments were assessed for presence or absence of any noncompaction by two blinded, experienced readers. An ROC curve was generated for sensitivity and specificity for LVNC compared to other groups in the study cohort.
The authors conclude that an end-diastolic noncompacted:compacted ratio of greater than 2.3 distinguished pathologic LVNC from other conditions with 88% sensitivity, 97% specificity, 78% positive predictive value, and 99% negative predictive value.
Other recent JTI articles on LVNC:
NA Zenooz et al. Noncompaction Syndrome of the Myocardium: Pathophysiology and Imaging Pearls
H Ito et and KH Dahani. A Case With Noncompaction of the Left Ventricular Myocardium Detected by 64-slice Multidetector Computed Tomography