Web Exclusive Content: Pictorial EssayDual-energy Subtraction Chest Radiography Application in Cardiovascular ImagingAnsari-Gilani, Kianoush MD*; Tandon, Yasmeen K. MD*; Jordan, David W. PhD†; Ciancibello, Leslie RT†; Wilson, David L. PhD†; Gilkeson, Robert C. MD*Author Information *University Hospital Cleveland Medical Center †Department of Radiology, University Hospitals Cleveland Medical Center & Case Western Reserve University, Cleveland, OH The authors declare no conflicts of interest. Correspondence to: Kianoush Ansari-Gilani, MD, Radiology Department, University Hospital Cleveland Medical Center, 11100 Euclid Avenue, Cleveland, OH 44124 (e-mail: email@example.com). Journal of Thoracic Imaging: May 2020 - Volume 35 - Issue 3 - p W75-W81 doi: 10.1097/RTI.0000000000000472 Buy Metrics Abstract The chest radiograph is the most frequently performed imaging in radiology and by including the heart and central vessels can suggest the presence of cardiovascular disease. Dual-energy subtraction radiography of the chest provides improved detection of a wide variety of cardiovascular pathologies including coronary artery disease, valvular pathologies, and pericardial disease given the presence of calcification in many subtypes of these diseases. We review the principles of dual-energy subtraction radiography and demonstrate its added value in the assessment of cardiovascular disease. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.