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Pulmonary Manifestations of Common Variable Immunodeficiency

Bang, Tami J., MD*; Richards, John Caleb, MD; Olson, Amy L., MD; Groshong, Steve D., MD§; Gelfand, Erwin W., MD; Lynch, David A., MB

doi: 10.1097/RTI.0000000000000350
Infection

Common variable immunodeficiency (CVID) is associated with significant chronic lung disease. The purpose of this paper was to describe the clinical, radiologic, and pathologic findings of CVID-associated lung diseases. These include airways’ disease, interstitial lung disease, lymphoma, and mucosa-associated lymphoid tissue lymphoma. In addition, a genetic syndrome termed Kabuki syndrome results in CVID-like immune abnormalities. These patients may also present with CVID-associated lung disease. Awareness and precise identification of CVID-associated lung disease may allow for better assessment of prognosis and direction of therapy.

*Department of Radiology, University of Colorado School of Medicine, Aurora

Departments of Radiology

Medicine, Division of Pulmonary, Critical Care and Sleep Medicine

§ Medicine, Division of Pathology

Pediatrics, Division of Pediatric Allergy and Clinical Immunology, National Jewish Health, Denver, CO

J.C.R. is a consultant for Boehringer Ingelheim. D.A.L. is a consultant for Parexel, Boehringer Ingelheim, Genentech, Gilead, and Veracyte. D.A.L. also provides research support for Siemens Inc. and NHLBI. The remaining authors declare no conflicts of interest.

Correspondence to: Tami J. Bang, MD, Department of Radiology, University of Colorado School of Medicine, Mail Stop L954, 12401 E 17th Avenue, Aurora, CO 80045 (e-mail: tami.bang@ucdenver.edu).

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