Common variable immunodeficiency (CVID) is associated with significant chronic lung disease. The purpose of this paper was to describe the clinical, radiologic, and pathologic findings of CVID-associated lung diseases. These include airways’ disease, interstitial lung disease, lymphoma, and mucosa-associated lymphoid tissue lymphoma. In addition, a genetic syndrome termed Kabuki syndrome results in CVID-like immune abnormalities. These patients may also present with CVID-associated lung disease. Awareness and precise identification of CVID-associated lung disease may allow for better assessment of prognosis and direction of therapy.
*Department of Radiology, University of Colorado School of Medicine, Aurora
Departments of †Radiology
‡Medicine, Division of Pulmonary, Critical Care and Sleep Medicine
§ Medicine, Division of Pathology
∥Pediatrics, Division of Pediatric Allergy and Clinical Immunology, National Jewish Health, Denver, CO
J.C.R. is a consultant for Boehringer Ingelheim. D.A.L. is a consultant for Parexel, Boehringer Ingelheim, Genentech, Gilead, and Veracyte. D.A.L. also provides research support for Siemens Inc. and NHLBI. The remaining authors declare no conflicts of interest.
Correspondence to: Tami J. Bang, MD, Department of Radiology, University of Colorado School of Medicine, Mail Stop L954, 12401 E 17th Avenue, Aurora, CO 80045 (e-mail: firstname.lastname@example.org).