SA-CME ArticleComputed Tomography Angiographic Assessment of Acute Chest PainMiller, Matthew M. MD, PhD*; Ridge, Carole A. FFRRCSI†; Litmanovich, Diana E. MD‡ Author Information *Department of Radiology, Duke University Hospital, Durham, NC ‡Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA †Department of Radiology, Mater Misericordiae University Hospital, Dublin, Ireland Dr Miller is a Breast Imaging Fellow at Duke University Hospital, Durham, NC; Dr Litmanovich is an Associate Professor of Radiology in Cardiothoracic Imaging, Director of Cardiac CT, Director of Cardiothoracic Fellowship, and Director of Radiology Course for Primary Clinical Experience at Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA; Dr Ridge is a Consultant Radiologist at Mater Misericordiae University Hospital, Dublin, Ireland. The authors, faculty and all staff in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no financial relationships with, or financial interests in, any commercial organizations pertaining to this educational activity. Correspondence to: Diana E. Litmanovich, MD, Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215 (e-mail: [email protected]). Journal of Thoracic Imaging 32(3):p 137-150, May 2017. | DOI: 10.1097/RTI.0000000000000267 Buy CME Test Metrics Abstract Acute chest pain is a leading cause of Emergency Department visits. Computed tomography angiography plays a vital diagnostic role in such cases, but there are several common challenges associated with the imaging of acute chest pain, which, if unrecognized, can lead to an inconclusive or incorrect diagnosis. These imaging challenges fall broadly into 3 categories: (1) image acquisition, (2) image interpretation (including physiological and pathologic mimics), and (3) result communication. The aims of this review are to describe and illustrate the most common challenges in the imaging of acute chest pain and to provide solutions that will facilitate accurate diagnosis of the causes of acute chest pain in the emergency setting. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.