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Magnetic Resonance Imaging for Lung Cancer

Koyama, Hisanobu MD, PhD*; Ohno, Yoshiharu MD, PhD†,‡; Seki, Shinichiro MD*; Nishio, Mizuho MD*; Yoshikawa, Takeshi MD, PhD†,‡; Matsumoto, Sumiaki MD, PhD†,‡; Sugimura, Kazuro MD*

doi: 10.1097/RTI.0b013e31828d4234
Symposium Review Articles

Since the publication of the Radiologic Diagnostic Oncology Group Report in 1991, the clinical application of pulmonary magnetic resonance imaging (MRI) in patients with lung cancer has been limited. In contrast, MRI for lung cancer has undergone continuous development, and several promising techniques have been introduced to overcome the previously suggested limitations. In addition, comparative studies involving multidetector-row computed tomography and positron emission tomography or positron emission tomography/computed tomography with 2-deoxy-2-[18F]fluoro-D-glucose have shown useful new clinical applications for MRI in lung cancer. Moreover, MRI can provide not only morphologic information based on various parameters such as T1 and T2 relaxation times, tissue diffusion, perfusion, etc. but also functional information; it also has a significant role in nuclear medicine studies. In this review article, we describe recent advances made in MRI with respect to lung cancer, focusing on (1) detection of solid pulmonary nodules; (2) characterization of solid pulmonary nodules; (3) TNM staging assessment using chest and whole-body MRI examinations; (4) prediction of postsurgical lung function; and (5) prediction of tumor treatment response. We believe that further basic studies, as well as studies on clinical applications of new MRI techniques, are important for improving the management of lung cancer patients.

*Department of Radiology

Advanced Biomedical Imaging Research Center

Department of Radiology, Division of Functional and Diagnostic Imaging Research, Kobe University Graduate School of Medicine, Kobe, Japan

Drs Y. Ohno, M. Nishio, T. Yoshikawa, S. Matsumoto, and K. Sugimura have research grants from Toshiba Medical Systems. The remaining authors declare no conflicts of interest.

Reprints: Hisanobu Koyama, MD, PhD, Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan (e-mail:

© 2013 Lippincott Williams & Wilkins, Inc.